牙龈卟啉单胞菌:从毒力因子到疫苗研发  

Porphyromonas Gingivalis:From Virulence Factor to Vaccine Development

作　　者：李伟[1,2] 李智涛 王烁[1] 高社干 LI Wei;LI Zhitao;WANG Shuo;GAO Shegan(College of basic medicine and forensic medicine,Henan University of Science and Technology,Luoyang,China 4710003;Department of Stomatology,Xuchang Central Hospital,Xuchang Key Laboratory of Oral Microecology and Oral Diseases,Xuchang,China 461000;State Key Laboratory of Esophageal Cancer Prevention&Treatment,Hennan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment,Hennan Key Laboratory of Cancer Epigenetics,Cancer Hospital,The First Affiliated Hospital(College of Clinical Medicine)of Henan University of Science and Technology,Luoyang,China,471003)

机构地区：[1]河南科技大学基础医学与法医学院,河南洛阳471003 [2]许昌市中心医院口腔科,许昌市口腔微生态与口腔疾病重点实验室,河南许昌461000 [3]河南科技大学临床医学院,河南科技大学第一附属医院,肿瘤医院,省部共建食管癌防治国家重点实验室,河南省微生态与食管癌防治重点实验室,河南省肿瘤表观遗传重点实验室,洛阳471003

出　　处：《食管疾病》2024年第3期189-195,236,共8页Journal of Esophageal Diseases

基　　金：国家自然科学基金(81972571);许昌市重点研发与推广专项(科技攻关、软科学研究)备案项目(20230213093)。

摘　　要：牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)是革兰氏阴性口腔致病菌之一,其定植于牙龈内厌氧菌生物膜中,引起局部牙周炎。Pg由定植的牙龈局部通过体液扩散到全身引起多种疾病,如:心脑血管疾病、自身免疫性疾病、阿尔兹海默症、癌症等。药物难以到达牙龈部位且持续给药易引起菌体的耐药,不能达到根除的效果。因此,选择合适的抗原位点刺激机体免疫系统产生中和抗体是疫苗研究的关键。本文对Pg的致病及其机制进行了概括,并全面综述了相关的毒力因子,为清除和预防Pg感染提供靶标,同时从疫苗学角度评价和分析这些毒力因子作为疫苗的潜力。Porphyromonas gingivalis(Pg)has been proved to be one of gram-negative oral pathogens,which colonizes in the gingival anaerobe biofilm and causes local periodontitis.Pg spreads from colonized gums to other body parts through body fluids to cause a variety of systemic diseases,such as cardiovascular and cerebrovascular diseases,autoimmune diseases,Alzheimer’s disease,cancer.It is difficult for the drug to reach the gum and continuous administration of the drug is easy to cause drug resistance of the bacteria,and the eradication effect cannot be achieved.Therefore,the selection of appropriate antigen sites to stimulate the immune system to produce neutralizing antibodies is the key to vaccine research.In this paper,the pathogenesis and mechanism of Pg were summarized,and the related virulence factors were comprehensively reviewed to provide targets for the elimination and prevention of Pg infection,and the potential of these virulence factors as vaccines was evaluated and analyzed from the perspective of vaccinology.

关 键 词：牙龈卟啉单胞菌 毒力因子 疫苗 免疫原 

分 类 号：R186.3[医药卫生—流行病学]