生物抗菌材料在食管癌预防和诊疗中的研究进展  

Research Progress of Biological Antibacterial Materials in the Prevention and Treatment of Esophageal Cancer

作　　者：史嘉铭 李佳怡 郝思妤 喻莹 赵亚莉 张小漫 杨平娟 李宝生 石林林 高社干[1] SHI Jiaming;LI Jiayi;HAO Siyu;YU Ying;ZHAO Yali;ZHANG Xiaomang;YANG Pingjuan;LI Baosheng;SHI Linlin;GAO Shegan(School of Basic Medicine and Forensic Medicine,Henan University of Science and Technology,Henan Provincial Key Laboratory of Microbiology and Esophageal Cancer Prevention and Control,Luoyang,China,471003)

机构地区：[1]河南科技大学基础医学与法医学院,河南省微生物与食管癌防治重点实验室,河南省肿瘤表观遗传学重点实验室,河南科技大学第一附属医院,肿瘤医院,洛阳471003

出　　处：《食管疾病》2024年第3期196-201,共6页Journal of Esophageal Diseases

基　　金：河南省中原英才计划(育才系列);河南省医学科技攻关省部共建重点项目(SBGJ202102199);洛阳市社会发展公益专项医疗卫生重点项目(2302016A)。

摘　　要：食管癌作为上消化道中一种常见的恶性肿瘤,其发病过程与微生态紊乱密切相关。目前临床上标准治疗手段包括手术、化疗和放射治疗。近年来,抗菌生物材料在抗菌和抗肿瘤治疗方面崭露头角,不仅可以抑制细菌的生长和扩散,还可以作为药物的靶向递送载体。通过利用抗菌生物材料的靶向性和可控释放性,可以精确输送抗肿瘤药物到肿瘤组织内或肿瘤细胞内,从而抑制肿瘤细胞的增殖和转移,实现对肿瘤的精准治疗。抗菌生物材料具有良好的生物相容性和可降解性,在食管癌的预防和诊疗中具有巨大潜力。本文总结了生物抗菌材料在食管癌治疗中的最新进展及其治疗的安全性和有效性。Esophageal carcinoma,as a common malignant tumor in the upper digestive tract,is closely associated with dysbiosis.Current standard clinical treatments include surgery,chemotherapy,and radiotherapy.In recent years,antimicrobial biomaterials have emerged in the field of antibacterial and antitumor therapy.These materials not only inhibit the growth and spread of bacteria but also serve as drug carriers.By utilizing the targeting and controllable release properties of antimicrobial biomaterials,anti-tumor drugs can be precisely delivered to tumor tissues or tumor cells,thereby inhibiting tumor cell proliferation and metastasis,achieving precise tumor treatment.Antimicrobial biomaterials exhibit good biocompatibility and biodegradability,holding tremendous potential in the prevention and treatment of esophageal carcinoma.This review summarizes the latest advances of antimicrobial biomaterials in the treatment of esophageal carcinoma,as well as their safety and efficacy in therapy.

关 键 词：食管癌 微生态 生物抗菌材料 纳米载药 综合治疗 

分 类 号：R735.1[医药卫生—肿瘤]