甲地孕酮乙酸酯合成用钯炭催化剂研究  

Study on Palladium-Carbon Catalyst for Synthesis of Megestrol Acetate

作　　者：翟康 张磊 张鹏 王昭文 李岳锋 ZHAI Kang;ZHANG Lei;ZHANG Peng;WANG Zhaowen;LI Yuefeng(Kaili Catalyst&New Materials Co.,Ltd.,Xi’an Shaanxi 710201,China;Shaanxi Engineering Research Center of Noble Metal Catalyst,Xi’an Shaanxi 710201,China;Shaanxi Key Laboratory of Catalytic Materials and Technology,Xi’an Shaanxi 710201,China)

机构地区：[1]西安凯立新材料股份有限公司,陕西西安710201 [2]陕西省贵金属催化剂工程研究中心,陕西西安710201 [3]陕西省催化材料与技术重点实验室,陕西西安710201

出　　处：《当代化工》2024年第9期2263-2266,共4页Contemporary Chemical Industry

基　　金：国家重点研发计划“催化科学”重点专项2022年度项目(项目编号:2022YFA1503504);陕西省自然科学基础研究计划项目(项目编号:2023-JC-QN-0158);陕西省自然科学基础研究计划项目(项目编号:2022JQ-152)。

摘　　要：甲地孕酮乙酸酯属于甾体类化合物,是重要的孕激素类药物。研究以6-亚甲基孕酮乙酸酯作为原料在Pd/C催化剂和助剂等作用下,发生结构B上的环外双键异构化反应生成甲地孕酮乙酸酯。实验主要探究催化剂质量、反应时间、反应温度、反应转速、环己烯质量及乙酸钠质量对合成甲地孕酮乙酸酯的影响,同时在最佳合成反应条件下研究不同盐溶液后处理的催化剂对反应效果的影响。Megestrol acetate belongs to steroid compounds and is an important progestational drug.Using 6-methyleneprogesterone acetate as the raw material,under the action of Pd/C catalyst and additives,the formation of megestrol acetate through isomerization reaction of exocyclic double bonds on structure B was studied.The effects amount of catalyst,reaction time,reaction temperature,reaction rotation speed,amount of cycloidal and amount of sodium acetate on synthesis of megestrol acetate were investigated.At the same time,the influence of catalyst post-treatment with different salt solutions on the reaction effect was studied under the optimal synthesis reaction conditions.

关 键 词：甲地孕酮乙酸酯 6-亚甲基孕酮乙酸酯 钯炭 催化剂 

分 类 号：TQ426.6[化学工程]