Modeling solubility of oxaprozin and irbesartan in biorelevant complex solutions based on a combination of pH-dependent and micellar solubilization models  

作　　者：Chen Shen Yuanhui Ji 

机构地区：[1]Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research,School of Chemistry and Chemical Engineering,Southeast University,Nanjing 211189,China

出　　处：《Chinese Journal of Chemical Engineering》2024年第8期34-43,共10页中国化学工程学报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(22278070,21978047,21776046)。

摘　　要：Biological solubility is one of the important basic parameters in the development process of poorly soluble drugs,but the current measurement methods are mainly based on a large number of experiments,which are time-consuming and cost-intensive.There is still a lack of effective theoretical models to accurately describe and predict the biological solubility of drugs to reduce costs.Therefore,in this study,osaprazole and irbesartan were selected as model drugs,and their solubility in solutions containing surfactants and biorelevant media was measured experimentally.By calculating the parameters of each component using the perturbed-chain statistical associating fluid theory(PC-SAFT)model,combined with pH-dependent and micellar solubilization models,the thermodynamic phase behavior of the two drugs was successfully modeled,and the predicted results were in good agreement with the experimental values.These results demonstrate that the model combination used provides important basic parameters and theoretical guidance for the development and screening of poorly soluble drugs and related formulations.

关 键 词：Biorelevant media pH-dependent solubility Micellar solubilization PC-SAFT Active pharmaceutical ingredients 

分 类 号：TQ460.1[化学工程—制药化工]