Targeting NRP1 axis as a strategy for treating energy metabolism impairment induced by SARS-CoV-2 spike  

作　　者：Lihui Zhang Wanting Hu Jingxuan Li Yuehan Li Feng Liu Wenyi Xiao Ning Jiang Zhiyong Xiao Lu Han Wenxia Zhou 

机构地区：[1]Beijing Institute of Pharmacology&Toxicology,Beijing 100850,China [2]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology&Toxicology,Beijing 100850,China [3]School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Science China(Life Sciences)》2024年第10期2277-2279,共3页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(82141218);Young Elite Scientists Sponsorship Program by CAST(2022QNRC001);National Key Research and Development Program of China(2022YFC3500304)。

摘　　要：Dear Editor,Free spike protein of SARS-CoV-2 alone can cause abnormal energy metabolism(Table S1 in Supporting Information),and limited research suggested a potential correlation between spike-induced mitochondrial damage and the ACE2 receptor(Lei et al.,2021;Yang et al.,2023).

关 键 词：METABOLISM ACE2 

分 类 号：R373[医药卫生—病原生物学]