妊娠晚期B族溶血性链球菌宫内感染患者血清IL-1β和IL-10表达与阴道微生态及妊娠结局的关系  

Relationship between serum IL-1βand IL-10 expression with vaginal microbiota and pregnancy outcomes in patients with intrauterine infection of Group B hemolytic streptococci in late pregnancy

作　　者：巴特 刘飞飞 宋娇 BA Te;LIU Feifei;SONG Jiao(The First Department of Obstetrics,Shengjing Hospital of China Med University,Shenyang,Liaoning 110000,China)

机构地区：[1]中国医科大学附属盛京医院第一产科病,辽宁沈阳110000

出　　处：《中国病原生物学杂志》2024年第11期1255-1259,共5页Journal of Pathogen Biology

摘　　要：目的了解妊娠晚期B族溶血性链球菌(GBS)宫内感染患者血清白介素-1β(IL-1β)和白介素-10(IL-10)表达水平,以及与阴道微生态及妊娠结局的关系。方法选择2019年10月-2024年1月收治的239例妊娠晚期孕妇作为研究对象,依据是否发生宫内感染分为GBS感染组(68例)及未感染组(171例)。依据GBS感染患者妊娠情况分为良好妊娠组(42例)及不良妊娠组(26例)。收集患者一般资料,采用酶联免疫吸附法(ELISA)检测患者血清IL-1β和IL-10水平,分析GBS感染患者血清IL-1β和IL-10水平与不同阴道微环境的关系,比较不同妊娠结局患者实验室指标及血清IL-1β和IL-10水平,多因素Logistic回归分析GBS感染患者不良妊娠结局的影响因素,采用受试者工作特征(ROC)曲线分析血清IL-1β和IL-10水平对GBS感染患者不良妊娠结局的诊断价值。结果GBS感染组患者血清IL-1β、IL-10水平高于未感染组(P<0.05),GBS感染患者血清IL-1β、IL-10水平与Nugent评分、阴道清洁度及pH值有关(P<0.05),不良妊娠组患者E_(2)、HbA1c、IL-1β及IL-10水平高于良好妊娠组(P<0.05),血清IL-1β(95%CI:1.649-9.108)、IL-10(95%CI:1.483-11.701)水平是GBS感染患者不良妊娠结局的影响因素(P<0.05),血清IL-1β、IL-10联合诊断GBS感染患者不良妊娠结局的AUC高于IL-1β单独诊断的AUC(Z=2.088,P=0.037)、高于IL-10单独诊断的AUC(Z=2.038,P=0.042)。结论妊娠晚期GBS感染患者血清IL-1β、IL-10水平升高,其水平变化与阴道微生态及妊娠结局相关。Objective To detect the expression levels of serum interleukin-1β(IL-1β)and interleukin-10(IL-1β)in patients with intrauterine infection of Group B hemolytic streptococci(GBS)in late pregnancy,and to study their relationship with vaginal microbiota and pregnancy outcomes.Methods This study selected 239 late pregnancy pregnant women admitted from October 2019 to January 2024 as the research subjects.They were separated into GBS infection group(68 cases)and non infection group(171 cases)based on whether intrauterine infection occurred.According to the pregnancy status of GBS infected patients,they were separated into a good pregnancy group(42 cases)and an adverse pregnancy group(26 cases).General information of the patients was collected.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum IL-1βand IL-1β levels in patients.The relationship between serum IL-1βand IL-1β levels with different vaginal microenvironments in GBS infected patients was analyzed.Laboratory indicators and serum IL-1βand IL-1β levels were compared among patients with different pregnancy outcomes.Multivariate logistic regression was applied to analyze the influencing factors of adverse pregnancy outcomes in GBS infected patients.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum IL-1βand IL-1β levels for adverse pregnancy outcomes in GBS infected patients.Results The serum levels of IL-1βand IL-10 in the GBS infection group were higher than those in the non infection group(P<0.05).The serum levels of IL-1βand IL-10 in GBS infected patients were correlated with Nugent score,vaginal cleanliness,and pH value(P<0.05).The levels of E_(2),HbA1c,IL-1β,and IL-10 in the poor pregnancy group were higher than those in the good pregnancy group(P<0.05).The serum levels of IL-1β(95%CI:1.649-9.108)and IL-10(95%CI:1.483-11.701)were influencing factors for adverse pregnancy outcomes in GBS infected patients(P<0.05).The AUC of the combination of serum IL-1βand IL-10 in diagnosing advers

关 键 词：B族溶血性链球菌 妊娠晚期 宫内感染 白介素-1β 白介素-10 阴道微生态 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]