铜绿假单胞菌的耐药机制及群体感应研究进展  

Research progress on the drug resistance mechanism and quorum sensing of Pseudomonas aeruginosa

作　　者：赵育林 林艳[1] 韩卫南 石露露 王树[3] 张双红 韩博[1] ZHAO Yulin;LIN Yan;HAN Weinan;SHI Lulu;WANG Shu;ZHANG Shuanghong;HAN Bo(Zhangjiakou University,Zhangjiakou 075000,Hebei,China;Zhangjiakou First Hospital;Hebei Nouth University)

机构地区：[1]张家口学院,河北张家口075000 [2]张家口市第一医院 [3]河北北方学院

出　　处：《中国病原生物学杂志》2024年第11期1377-1380,共4页Journal of Pathogen Biology

基　　金：河北省高等教育教学改革研究与实践项目(No.2023GJJG595)。

摘　　要：铜绿假单胞菌是临床上常见的条件致病菌,也是医院感染的重要病原体,在多种感染中分离率高,且对多种抗生素耐药。其耐药机制包括获得耐药基因、膜透性改变、药物外排泵表达、改变菌体表面电荷等。群体感应系统在调控菌体生物被膜形成、致病性和耐药性方面起关键作用,该系统包括Las、Rhl、PQS等,研究者正探索通过干扰此系统来削弱致病性和耐药性。对铜绿假单胞菌的群体感应系统及其耐药机制的研究,不仅有助于揭示其生物学特性,还能为开发新型抗感染药物和治疗策略提供依据。未来需将研究成果转化为临床应用,以控制感染。Pseudomonas aeruginosa is a common opportunistic pathogen in clinical practice and an important pathogen for hospital infections.It has a high isolation rate in various infections and is resistant to many antibiotics.Its resistance mechanisms include obtaining resistance genes,changes in membrane permeability,expression of drug efflux pumps,and changes in the surface charge of the bacteria,etc.The quorum sensing system plays a key role in regulating the formation of bacterial biofilms,pathogenicity,and drug resistance.This system includes Las,Rhl,PQS,etc.Researchers are exploring ways to weaken pathogenicity and drug resistance by interfering with this system.Research on the quorum sensing system and drug resistance mechanisms of P.aeruginosa not only helps reveal its biological characteristics but also provides a basis for the development of new anti-infective drugs and treatment strategies.In the future,research results need to be translated into clinical applications to control infections.

关 键 词：铜绿假单胞菌 耐药机制 群体感应 综述 

分 类 号：R446.5[医药卫生—诊断学]