脂质代谢调控炎症反应在疼痛研究的进展  

Progress of lipid metabolism regulating inflammatory response in pain research

作　　者：张弋珂 韩超峰 Zhang Yike;Han Chaofeng(Department of Histology and Embryology,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学组织胚胎学教研室,上海200433

出　　处：《解剖学杂志》2024年第4期283-288,共6页Chinese Journal of Anatomy

基　　金：国家自然科学基金(82471792)。

摘　　要：疼痛是一种复杂的生理和病理过程,涉及多个生物学过程和信号通路。近年研究表明,脂质代谢异常和炎症反应在疼痛的发生和发展中起着重要作用。脂质代谢调控炎症反应对疼痛的调控具有关键影响。本综述将探讨脂质代谢与炎症反应在疼痛中的相互作用及其对疼痛发展与消退的影响,包括痛觉敏化以及小胶质细胞在这些过程中的作用。Pain is a complex physiological and pathological phenomenon,governed by numerous biological processes and signaling pathways.Recent research identified lipid metabolism abnormalities and inflammatory responses as crucial roles in the occurrence and development of pain.The regulation of inflammatory response by lipid metabolism exerts a profound influence on pain management.This review delves into the dynamics between lipid metabolism and inflammation in pain,examining their effects on its development and resolution,including the nociceptive sensitization and the involvement of microglial cells in these processes.

关 键 词：脂质代谢 神经炎症 小胶质细胞 疼痛 痛觉敏化 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]