同种异体带瓣管道的研究进展  

Research progress on valved homograft conduits

作　　者：刘子钰 杨斌 郭志坤[1] Liu Ziyu;Yang Bin;Guo Zhikun(Henan Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical University,Xinxiang 453003;Department of Cardiothoracic Surgery,The 7th People's Hospital of Zhengzhou,Zhengzhou 453000,China)

机构地区：[1]新乡医学院河南省医用组织再生重点实验室,新乡453003 [2]郑州第七人民医院心外科,郑州453000

出　　处：《解剖学杂志》2024年第4期348-351,共4页Chinese Journal of Anatomy

基　　金：河南省科技攻关项目(LHGJ20220837)。

摘　　要：根治复杂性心瓣膜病需采用心外管道,目前心外管道有人工材料、同种异体带瓣管道(VHC)及异种带瓣管道。VHC具有符合人体的抗钙化、抗感染和无需终生抗凝等生理特点,然而VHC仍存在供体短缺和无法长期保存等问题,导致其无法被大力推广,但深低温保存技术有望解决长期保存这一问题。笔者综述了VHC供体的筛选、保存方法及其临床应用的研究进展,为VHC在临床上对左、右心室流出道的重建提供参考。To treat complex valvular heart dis ease,cardiovascular conduits are necessary.These conduits can be made from artificial materials,valved homograft conduits(VHC),or valved xenograft conduits.VHC offer physiological advantages,including resistance to calcification and infection,and do not require lifelong anticoagulation,making them highly compatible with the human body.However,the shortage of donors and the inability to store VHC for a long time have impeded their widespread adoption.The cryopreservation technology is expected to solve this problem.This article reviews the progress in donor selection,preservation methods,and clinical applications of VHC,providing valuable insights for its reconstruction of left and right ventricular outflow tract in clinical use.

关 键 词：同种异体带瓣管道 脱细胞 低温保存 

分 类 号：R322.1[医药卫生—人体解剖和组织胚胎学]