何首乌抗性淀粉-玉米醇溶蛋白负载酯蟾毒配基纳米粒的制备及工艺优化  

Preparation and Process Optimization of Polygonum multiflorum-Resistant Starch-Zein-Loaded Ester Bufogenin Nanoparticles

作　　者：韦利芬 王海燕 任涛 李昕瑜 阮婧华 辛加敏 查鑫 王聪 谭荣 WEI Lifen;WANG Haiyan;REN Tao;LI Xinyu;RUAN Jinghua;XIN Jiamin;ZHA Xin;WANG Cong;TAN Rong(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]贵州中医药大学第一附属医院,贵州贵阳550001

出　　处：《现代食品》2024年第14期121-123,共3页Modern Food

基　　金：国家自然科学基金地区科学基金项目(82060643);国家自然科学基金地区科学基金项目(82360779);贵州省科技计划项目(黔科合平台人才[2021]5621);贵州省中医药管理局中医药、民族药科学技术课题(QZYY-2023-105)。

摘　　要：为了改善酯蟾毒配基的成药性,提高其生物利用度,本文通过反溶剂法制备了负载酯蟾毒配基的何首乌抗性淀粉-玉米醇溶蛋白纳米粒,以包封率为指标,采用单因素实验和正交试验进行纳米粒制备工艺的优化。优化后的制备工艺为pH值为4,搅拌速度为400 r·min^(-1),何首乌抗性淀粉和玉米醇溶蛋白比例为1∶1,玉米醇溶蛋白和酯蟾毒配基比例为1∶1,制备的纳米粒包封率为86.84%。In order to improve the drug properties of ester bufogenin and increase its bioavailability,Polygonum polygonatum resistant starch-zein nanoparticles were prepared by reverse-solvent method.Single factor and orthogonal experiments were used to optimize the preparation process with the encapsulation rate as the index.The optimized preparation process was as follows:pH 4,stirring speed 400 r·min^(-1),ratio of resistant starch to zein 1∶1,ratio of zein to esterbufogenin 1∶1,the encapsulation rate of prepared nanoparticles was 86.84%.

关 键 词：酯蟾毒配基 何首乌抗性淀粉 反溶剂法 纳米粒 工艺优化 

分 类 号：R282.4[医药卫生—中药学]