双网络抗菌水凝胶基棉织物敷料的制备及性能研究  

Preparation and properties of dual-network antibacterial hydrogel-based cotton fabric dressings

作　　者：陈雨 邱华 陈坤林 Chen Yu;Qiu Hua;Chen Kunlin(Key Laboratory of Eco-textiles of Ministry of Education,College of Textile Science and Engineering,Jiangnan University,Wuxi 214122)

机构地区：[1]江南大学纺织科学与工程学院生态纺织教育部重点实验室,无锡214122

出　　处：《化工新型材料》2024年第10期282-286,共5页New Chemical Materials

基　　金：国家中医药管理局创新团队与人才培养计划(ZYYCXTD-D-202206)。

摘　　要：功能性敷料对于伤口愈合具有重要作用。针对水凝胶力学性能较差,传统棉织物易与伤口发生粘连等问题,制备了一种三明治结构的水凝胶基棉织物敷料。首先将棉织物进行阴离子、抗菌改性,然后以聚乙烯醇/壳聚糖季铵盐/聚丙烯酰胺(PVA/HACC/PAM)为水凝胶溶液,与改性棉织物通过物理、化学双交联的方法复合,制得水凝胶基棉织物敷料(PHPC)。结果表明,PHPC具有优异的力学性能、溶胀率,能有效避免液体污染和粘附;细胞活力为90.08%,抑菌率大于99%,表明该敷料在具备良好生物相容性的同时能够高效抗菌。Functional dressings play an important role in wound healing.To address the problems of poor mechanical properties of hydrogels and the adhesion of traditional cotton fabrics to wounds,a hydrogel-based cotton fabric dressing with a sandwich structure was prepared.Firstly,the cotton fabric was modified with anion and antibacterial,and then polyvinyl alcohol/chitosan quaternary ammonium salt/polyacrylamide(PVA/HACC/PAM)was used as a hydrogel solution and combined with the modified cotton fabric by physical and chemical double cross-linking method to prepare the hydrogel-based cotton fabric dressing(PHPC).The results showed that PHPC had excellent mechanical properties,swelling rate,and could effectively avoid liquid contamination and adhesion.The cell viability was 90.08%,and the antibacterial rate was more than 99%,indicating that the dressing could be efficiently antibacterial while possessing good biocompatibility.

关 键 词：水凝胶 棉织物 力学性能 抑菌率 伤口敷料 

分 类 号：TS101.8[轻工技术与工程—纺织工程] TB333[轻工技术与工程—纺织科学与工程]