坦布苏病毒分子致病机制研究进展  

Progress on Molecular Pathogenesis of Tembusu Virus

作　　者：陈玉明 崔德福 白小飞 乔仕承 侯世豪 周子彻 王跃扬 刘永相 CHEN Yuming;CUI Defu;BAI Xiaofei;QIAO Shicheng;HOU Shihao;ZHOU Ziche;WANG Yueyang;LIU Yongxiang(College of Life Sciences and Food Engineering,Hebei University of Engineering,Handan,Hebei 056038;Hebei Leshou Duck Industry Co.,Ltd.,Cangzhou,Hebei 062250;National Research Center for Veterinary Medicine,Luoyang,Henan 471003)

机构地区：[1]河北工程大学生命科学与食品工程学院,河北邯郸056038 [2]河北乐寿鸭业有限责任公司,河北沧州062250 [3]国家兽用药品工程技术研究中心,河南洛阳471003

出　　处：《中国家禽》2024年第10期152-157,共6页China Poultry

基　　金：河北省自然科学基金项目(C2021402005)。

摘　　要：坦布苏病毒(Tembusu virus,TMUV)感染可引起鸭的急性传染病,导致神经系统和生殖系统等的损伤,该病毒的广泛传播给我国养鸭业带来了严重的损失。TMUV除感染鸭外,还可以感染鹅、鸡等禽类,对我国养禽业有较大威胁。文章综述了TMUV与天然免疫系统、细胞凋亡、自噬、泛素-蛋白酶体系统、微小核糖核酸等的关系,为TMUV致病机制的深入研究和TMUV感染的科学防控提供理论参考。Tembusu virus(TMUV)infection causes acute disease to duck with damages of nervous and reproductive systems,leading to great losses to duck breeding farms in China due to its widespread dissemination.In addition to ducks,TMUV can also infect other poultry such as goose and chicken,posing a great threat to the poultry industry in China.The article focused on the relationships between TMUV and cellular innate immune system,cell apoptosis,autophagy,ubiquitin-proteasome system,microRNA,etc,to provide theoretical reference for further detailed study about pathogenesis of TMUV and scientific prevention and control of TMUV infection.

关 键 词：坦布苏病毒 分子致病机制 天然免疫 细胞凋亡 自噬 泛素-蛋白酶体系统 

分 类 号：S855.3[农业科学—临床兽医学]