二氧化硅包载对维生素C稳定性提高的研究  

Study on the silicon dioxide encapsulation for the enhancement of vitamin C stability

作　　者：石美玲 陈娟博 李皓 黄员琴 张启清 曾飒 孟涛[1] Meiling Shi;Juanbo Chen;Hao Li;Yuanqin Huang;Qiqing Zhang;Sa Zeng;Tao Meng(School of Life Sciences&Engineering,Southwest Jiaotong University,Chengdu,Sichuan 610031,China;Guangzhou Ridgepole Biological Technology Co.,Ltd.,Guangzhou,Guangdong 510800,China)

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031 [2]广州栋方生物科技股份有限公司,广东广州510800

出　　处：《日用化学工业（中英文）》2024年第9期1015-1022,共8页China Surfactant Detergent & Cosmetics

基　　金：国家自然科学基金资助项目(22378336,22204130);四川省科技厅重点研发项目(2020YFG0092,2021YFN0129);企业联合项目(R111322H01008)。

摘　　要：针对化妆护肤用品中亲水活性成分维生素C(Vc)稳定性差的问题,采用二氧化硅负载Vc(Vc@SiO_(2))并通过硅烷改性(Vc@s-SiO_(2))分散在辛酸/癸酸甘油三酯(GTCC)油相体系中提升其稳定性。实验结果表明:Vc负载于二氧化硅中,包封率为68.2%、载药率为13.6%;改性后Vc@s-SiO_(2)表面疏水,接触角由33.6°增大为130.7°;分别在紫外光照射和50℃下静置时,Vc@s-SiO_(2)相较于游离Vc能相应提高11.4倍和27.7倍相对抗氧化活性。研究表明二氧化硅负载Vc并分散于GTCC中能够隔绝水和氧等不利因素,降低活性损失,提高Vc的稳定性。To improve the stability of vitamin C(Vc)in cosmetics,Vc was coated with silica dioxide(Vc@SiO_(2)),modified by silane(Vc@s-SiO_(2))and dispersed in decanoyl/octanoyl-glycerides(GTCC)oil phase system.The experimental results show that the encapsulation rate and drug loading rate are 68.2%and 13.6%,respectively,when Vc is encapsulated into silica dioxide.After modification,the surface of Vc@s-SiO_(2) is hydrophobic and the contact angle increases from 33.6°to 130.7°.When Vc is maintained at 50℃or exposed to ultraviolet light,Vc@s-SiO_(2) exhibits an increase in antioxidant activity by 11.4 times and 27.7 times,respectively,compared to free Vc.This study reveals that silica dioxide coated Vc and dispersed in GTCC can isolate the adverse factors such as water oxygen,reduce the activity loss and improve the stability of Vc.

关 键 词：生物活性物 二氧化硅 维生素C 硅烷改性 稳定性 

分 类 号：TQ658[化学工程—精细化工]