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作 者:尤孝鹏 彭宁 陈智仙 Xiaopeng You;Ning Peng;Zhixian Chen(National Key Laboratory of Agricultural Microbiology,Yichang,Hubei 443003,China;The Hubei Provincial Key Laboratory of Yeast Function,Yichang,Hubei 443003,China;Yi Chang Engineering and Technology Research Center of Nutrition and Health Food,Yichang,Hubei 443003,China)
机构地区:[1]农业微生物资源发掘与利用全国重点实验室,湖北宜昌443003 [2]酵母功能湖北省重点实验室,湖北宜昌443003 [3]宜昌市营养健康食品工程技术研究中心,湖北宜昌443003
出 处:《日用化学工业(中英文)》2024年第9期1099-1105,共7页China Surfactant Detergent & Cosmetics
摘 要:从人体安全性、控油去屑功效、毛囊养护等方面初步认识酵母菌/锌发酵产物在头皮护理方面的功效。通过人体斑贴试验测试酵母菌/锌发酵产物的人体安全性;使用体外SZ95细胞模型研究酵母菌/锌发酵产物的控油功效,并使用qRT-PCR法验证油脂分泌相关基因SREBP-1c,PPARG和PI3K的表达;采用分光光度法测试酵母菌/锌发酵产物对5α-还原酶的抑制率;通过人体功效测试和离体毛囊模型分别研究酵母菌/锌发酵产物对头皮油脂的抑制效果和对毛囊的养护作用。结果表明:5%含量的酵母菌/锌发酵产物对人体安全隐患较小;0.8%~1.5%含量的酵母菌/锌发酵产物均可显著抑制5α-还原酶的活性;0.5%~2.0%含量的酵母菌/锌发酵产物均可显著抑制体外SZ95细胞油脂的分泌,并显著下调与油脂分泌相关基因SREBP-1c和PPARG的表达,1.0%、2.0%含量的酵母菌/锌发酵产物可显著抑制PI3K的表达;5%含量的酵母菌/锌发酵可显著降低头皮油脂分泌量,并具有改善毛囊周期和促进毛干增长的作用。因此,酵母菌/锌发酵产物具有一定头皮护理功效,在控油、改善毛囊健康、促进毛干生长等方面具有积极作用。The efficacy of yeast/zinc fermentation products in scalp care were studied from the aspects of safety,oil control and dandruff removal,and hair follicle maintenance.The safety of yeast/zinc fermentation products was tested through human patch testing.In vitro SZ95 cell model was used to study the oil-control efficacy of yeast/zinc fermentation products.The method of qRT-PCR was used to verify the expression of oil-secretion-related genes SREBP-1c,PPARG,and PI3K.Spectrophotometry was used to test the effect of yeast/zinc fermentation products on 5α-reductase.The oil-control effect of yeast/zinc fermentation products on scalp and the maintenance effect on hair follicles were studied through human efficacy testing and in vitro hair follicle model,respectively.The results showed that the yeast/zinc fermentation products at a content of 5%was safe and harmless to human health;the yeast/zinc fermentation products with a content of 0.8%-1.5%could significantly inhibit the activity of 5α-reductase.The yeast/zinc fermentation products at a content of 0.5%-2.0%could significantly inhibit the secretion of oil in SZ95 cells in vitro,and significantly downregulate the expression of oil-secretion-related genes SREBP-1c and PPARG.The yeast/zinc fermentation products at content of 1.0%and 2.0%could significantly inhibit the expression of PI3K.The yeast/zinc fermentation products at a content of 5%could significantly reduce scalp oil secretion,improve hair follicle cycle,and promote hair shaft growth.Therefore,the yeast/zinc fermentation products had certain scalp care effects and had positive effects in controlling oil,improving hair follicle health,and promoting hair shaft growth.
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