清肺饮治疗小儿腺病毒肺炎的疗效观察及其对肺功能和IL-17a、IL-6的影响  

Clinical Observation on Curative Effect of Qingfei Yin(清肺饮)in Treatment of Paediatric Adenovirus Pneumonia and Effects on Lung Function and IL-17a and IL-6

作　　者：章首苑 何潆 ZHANG Shouyuan;HE Ying(Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou Red Cross Hospital,Hangzhou,Zhejiang 310003)

机构地区：[1]浙江省中西医结合医院,杭州市红十字会医院,浙江杭州310003

出　　处：《中国中医药科技》2024年第5期773-775,814,共4页Chinese Journal of Traditional Medical Science and Technology

基　　金：浙江省中医药科技计划项目(2020ZB188);浙江省杭州市医药卫生科技项目(A20230079)。

摘　　要：目的:观察清肺饮治疗小儿腺病毒肺炎(adenovirus pneumonia,AP)的疗效及其对肺功能及白细胞介素-17a(interleukin-17a,IL-17a)、白细胞介素-6(interleukin-6,IL-6)的影响。方法:随机数字表法将本院2019年5月—2022年5月收治的60例风热袭肺证AP患儿分为对照组(30例)与观察组(30例),对照组给予常规治疗,观察组在对照组基础上给予清肺饮治疗,两组患儿连续用药15 d,记录两组患儿症状、体征消失时间,治疗前后检测肺功能及血清IL-17a、IL-6水平变化,记录用药期间不良反应。结果:与对照组比较,观察组总有效率显著提高(P<0.05);发热、咳嗽和鼻塞流涕消失时间均更短(P<0.05)。治疗后2组患儿肺呼吸功能指标均升高;相比对照组,观察组治疗后用FVC、FEV 1水平均更高(P<0.05)。治疗后2组患儿血清IL-6、IL-17a水平均降低;相比对照组,观察组治疗后IL-6、IL-17a水平均更低(P<0.05)。对照组不良反应发生率10.0%,观察组未见不良反应。结论:清肺饮治疗AP风热袭肺证患儿疗效显著,能改善肺功能和临床症状,缩短症状和体征消失时间,降低血清IL-17a、IL-6水平。Objective:To observe the clinical effect of Qingfei Yin in treatment of paediatric adenovirus pneumonia(AP)and effects on lung function and interleukin-17a(IL-17a)and interleukin-6(IL-6).Methods:A random number table method was used to divide 60 AP children with wind-heat attacking lung syndrome admitted to our hospital from May 2019 to May 2022 into the control group(30 cases)and the observation group(30 cases),the control group was given conventional treatment,and the observation group was given Qingfei Yin on the basis of the control group,both groups were treated for 15 days.The time of disappearance of symptoms and signs were recorded,the changes in traditional Chinese medicine symptom scores were recorded,lung function and IL-17a and IL-6 levels wer determined before and after treatment,the adverse effects were recorded.Results:To compared with the control group,the total effective rate on observation group was higher(P<0.05);Duration of fever,cough and nasal congestion and runny nose were shorter(P<0.05).Pulmonary function indicators in both groups were increased after treatment,FVC,FEV 1 and FEV1/FVC in the observation group were higher than those in control group(P<0.05).The levels of serum IL-6 and IL-17 a were reduced in the 2 groups after treatment and which were lower in the observation group to compared with the control group(P<0.05).The incidence of adverse reactions in the control group was 10.00%,and there were no adverse reactions in the observation group.Conclusion:Qinfei Yin can effectively treat AP children with wind-heat attacking lung syndrome,improve lung function and clinical symptoms,shorten the disappearance time of symptoms and signs,and reduce serum IL-17a and IL-6 levels.

关 键 词：小儿腺病毒肺炎 清肺饮 风热袭肺证 肺功能 L-17a IL-6 

分 类 号：R272[医药卫生—中医儿科学]