T细胞在天疱疮发病机制中的研究进展  

Role of T cells in the pathogenesis of pemphigus

作　　者：唐冬梅 闫雨柔 许银德 李晓岚[1] Tang Dongmei;Yan Yurou;Xu Yinde;Li Xiaolan(Department of Dermatology and Venereology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院皮肤性病科,昆明650101

出　　处：《中华皮肤科杂志》2024年第10期955-959,共5页Chinese Journal of Dermatology

摘　　要：天疱疮是一组危及生命的慢性自身免疫性疱病。目前认为抗桥粒芯糖蛋白IgG抗体介导的体液免疫是天疱疮发病的主要机制,而最近的研究显示,T细胞各亚类在天疱疮的发病中也起到关键作用。Pemphigus is a group of life-threatening chronic autoimmune blistering diseases.It is currently believed that the humoral immunity mediated by anti-desmoglein IgG antibodies is the primary mechanism underlying the pathogenesis of pemphigus.However,recent studies have indicated a critical role of various T cell subsets in the onset of pemphigus.

关 键 词：天疱疮 桥粒芯糖蛋白质类 CD4阳性T淋巴细胞 CD8阳性T淋巴细胞 T淋巴细胞 调节性 T淋巴细胞 辅助诱导 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]