银屑病生物制剂治疗对结核感染的影响及机制  

Effect of biotherapy for psoriasis on tuberculosis infection and relevant mechanisms

作　　者：汤自洁 王睿[2] 李承新 Tang Zijie;Wang Rui;Li Chengxin(Medical School of Chinese PLA,Department of Dermatology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Department of Dermatology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院、解放军总医院第一医学中心皮肤科,北京100853 [2]解放军总医院第一医学中心皮肤科,北京100853

出　　处：《中华皮肤科杂志》2024年第10期959-962,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81972936)。

摘　　要：近年生物制剂在银屑病,尤其是在重度难治性及特殊类型银屑病的治疗中发挥了积极作用,但其安全性也日益受到关注,尤以结核感染风险为著。本文针对不同作用靶点的生物制剂对结核的影响及其机制进行综述,为患者选择合适的生物制剂提供理论依据。In recent years,biological agents have played an active role in the treatment of psoriasis,especially for severe,refractory and special subtypes of psoriasis.However,their safety has attracted increasing attention,especially the risk of tuberculosis infection.This review summarizes the effect of biological agents with different targets on tuberculosis infection and relevant mechanisms,aiming to provide a theoretical basis for psoriasis patients to choose appropriate biotherapy.

关 键 词：银屑病 生物制剂 结核 潜伏性结核 生物治疗 

分 类 号：R52[医药卫生—内科学]