克立硼罗软膏在皮肤科中的应用进展  

Application of crisaborole ointment in dermatology

作　　者：杨思燕 马琳[2] 张斌[2] Yang Siyan;Ma Lin;Zhang Bin(Department of Dermatology,Henan Clinical Research Center of Childhood Diseases,Children′s Hospital Affiliated of Zhengzhou University,Henan Children′s Hospital Zhengzhou Children′s Hospital,Zhengzhou 450018,China;Department of Dermatology,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]郑州大学附属儿童医院、河南省儿童医院郑州儿童医院皮肤科、河南省儿科疾病临床医学研究中心,郑州450018 [2]国家儿童医学中心、首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《中华皮肤科杂志》2024年第10期962-966,共5页Chinese Journal of Dermatology

基　　金：北京市自然科学基金(7222058);河南省儿科疾病临床医学研究中心开放课题项目(YJZX202209);国家区域医疗中心开放课题项目(NRMC0101)。

摘　　要：克立硼罗是一种磷酸二酯酶4抑制剂,已在国内被批准用于轻度至中度特应性皮炎患者的治疗。此外,克立硼罗软膏也被报道成功治疗多种炎症性皮肤疾病。本文综述克立硼罗的作用机制及其在特应性皮炎、银屑病、白癜风、脂溢性皮炎、炎性线状疣状表皮痣、慢性单纯性苔藓、色素性痒疹、斑秃、浆细胞性龟头炎、扁平苔藓等皮肤疾病治疗中的研究进展。Crisaborole ointment,a phosphodiesterase-4 inhibitor,has been approved for the treatment of mild to moderate atopic dermatitis in China.In addition,crisaborole has been reported for the successful treatment of other inflammatory skin disorders.This review summarizes mechanisms of action of crisaborole and its application to the treatment of atopic dermatitis,psoriasis,vitiligo,seborrheic dermatitis,inflammatory linear verrucous epidermal nevus,lichen simplex chronicus,prurigo pigmentosa,alopecia areata,plasma cell balanitis,and lichen planus.

关 键 词：环核苷酸磷酸二酯酶类 4型 磷酸二酯酶4抑制剂 克立硼罗软膏 皮肤疾病 治疗 皮炎 特应性 银屑病 白癜风 

分 类 号：R986[医药卫生—药品]