氨溴索联合抗生素对老年慢性支气管炎急性发作期患者睡眠质量的影响  

Effect of Ambroxol Combined with Antibiotics on Sleep Quality in Elderly Patients with Acute Onset of Chronic Bronchitis

作　　者：侯新峰 HOU Xinfeng(Binzhou City,Shandong Province,Yangxin County Hospital of Traditional Chinese Medicine,Yangxin 251800,China)

机构地区：[1]山东省滨州市阳信县中医医院,阳信251800

出　　处：《世界睡眠医学杂志》2024年第7期1501-1503,共3页World Journal of Sleep Medicine

摘　　要：目的:阐明老年慢性支气管炎急性发作期的病理机制及治疗方向,分析氨溴索联合抗生素治疗的有效性。方法:选取2022年3月至2023年7月山东省滨州市阳信县中医医院呼吸与危重症医学科收治的老年慢性支气管炎急性发作期患者70例作为研究对象,按照随机数字表法分为对照组和观察组,每组35例。对照组给予常规抗生素治疗干预,观察组给予氨溴索联合抗生素治疗。比较2组患者干预前后的恢复情况,包括呼吸困难、咳嗽、湿啰音、住院时间,采用匹兹堡睡眠质量指数评价2组患者干预前后睡眠质量的变化,并比较2组患者肺功能的差异,包括呼气流量峰值(PEF)、第1秒用力呼气容积(FEV_(1))及其与用力肺活量(FVC)的比值(FEV_(1)/FVC),并比较2组患者的治疗有效率。结果:治疗后,观察组呼吸困难、咳嗽、湿啰音等症状评分显著低于对照组,观察组PSQI评分显著低于对照组,观察组患者肺功能各指标显著高于对照组,观察组治疗有效率显著高于对照组,差异均有统计学意义(均P<0.05)。结论:氨溴索联合抗生素有利于缓解常见症状,改善慢性支气管炎患者肺功能、睡眠情况,提高治疗有效性,值得临床推广应用。Objective:To elucidate the pathological mechanism and treatment direction of senile chronic bronchitis during acute attack,and to analyze the efficacy of ambroxol combined with antibiotics.Methods:A total of 70 patients with acute episodes of chronic bronchitis admitted to the Respiratory and Critical Care Medicine Department of Yangxin County Hospital of Traditional Chinese Medicine in Binzhou City,Shandong Province from March 2022 to July 2023 were selected as the research objects,and were divided into control group and observation group according to random number table method,with 35 cases in each group.The control group was given conventional treatment intervention,and the observation group was given ambroxol combined with antibiotics.The recovery of the two groups before and after intervention was compared,including dyspnea,cough,wet rales and length of hospital stay.The Pittsburgh sleep quality index was used to evaluate the changes in sleep quality of the two groups before and after intervention,and the differences in lung function between the two groups were compared.The peak expiratory flow(PEF),forced expiratory volume in the first second(FEV_(1))and its ratio to forced vital capacity(FVC)(FEV_(1)/FVC)were included,and the treatment effectiveness of the two groups was compared.Results:After treatment,the scores of dyspnea,cough,wet rales and other symptoms in the observation group were significantly lower than those in the control group,the PSQI scores in the observation group were significantly lower than those in the control group,the pulmonary function indexes in the observation group were significantly higher than those in the control group,and the treatment effective rate in the observation group was significantly higher than that in the control group,the difference between the two groups was statistically significant(P<0.05).Conclusion:Ambroxol combined with antibiotics can alleviate common symptoms,improve lung function and sleep in patients with chronic bronchitis,and improve treatment effective

关 键 词：慢性支气管炎 老年人 急性发作期 氨溴索 抗生素 联合治疗 疗效 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统] R338.63[医药卫生—内科学]