盐酸溴己新联合噻托溴铵吸入治疗慢性阻塞性肺疾病急性加重期疗效观察  

Observation on Therapeutic Effect of Bromhexine Hydrochloride Combined with Tiotropium Bromide Inhalation in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：孔令宇 韩进英 Kong Lingyu;Han Jinying(Zaozhuang Chest Hospital(Zaozhuang Tumor Hospital),Zaozhuang 277500,Shandong Province,China)

机构地区：[1]枣庄市胸科医院(枣庄市肿瘤医院),山东枣庄277500

出　　处：《中国社区医师》2024年第23期26-28,共3页Chinese Community Doctors

摘　　要：目的:探讨盐酸溴己新联合噻托溴铵吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:收集2022年12月—2023年6月枣庄市胸科医院(枣庄市肿瘤医院)治疗的AECOPD患者320例,随机分成观察组和对照组,各160例。对照组给予基础治疗联合头孢曲松钠、氨茶碱、盐酸溴己新治疗,观察组在对照组基础上应用噻托溴铵粉雾剂吸入治疗。比较两组患者治疗后临床症状消失时间及肺功能指标[第1秒用力呼气容积(FEV1)、最大呼气峰流速(PEFR)、第1秒用力呼出量占肺活量的百分比(FEV1/FVC)]情况。结果:观察组患者治疗后咳嗽、咳痰、气促、胸闷、肺部啰音消失时间明显短于对照组,差异有统计学意义(P<0.05)。两组患者治疗后,PEFR、FEV1和FEV1/FVC水平明显高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:盐酸溴己新联合噻托溴铵吸入治疗可以明显改善AECOPD患者的临床症状,提高肺功能水平,疗效显著,值得推广。Objective:To investigate the clinical efficacy of bromhexine hydrochloride combined with tiotropium bromide inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 320 patients with AECOPD who were treated at Zaozhuang Chest Hospital(Zaozhuang Tumor Hospital)from December 2022 to June 2022 were collected.They were randomly divided into observation group and control group with 160 patients in each group.The control group received basic treatment plus ceftriaxone sodium,aminophylline and bromhexine hydrochloride treatment,and the observation received Tiotropium Bromide Powder for Inhalation on the basis of the control group.The disappearance time of clinical symptoms and pulmonary function indexes[forced expiratory volume in 1 second(FEV1),peak expiratory flow rate(PEFR),and forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC)]were compared between the two groups.Results:After treatment,the disappearance time of cough,expectoration,shortness of breath,chest tightness and pulmonary rales in the observation group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of PEFR,FEV1 and FEV1/FVC in the two groups were significantly higher than those before treatment,and the levels in the observation group were higher than those in the control group,with a statistically significant difference(P<0.05).Conclusion:Bromhexine hydrochloride combined with tiotropium bromide inhalation therapy can significantly improve the clinical symptoms of patients with AECOPD,and improve the level of lung function,with significant efficacy,it is worthy of promotion.

关 键 词：慢性阻塞性肺疾病急性加重期 盐酸溴己新 噻托溴铵 

分 类 号：R563.9[医药卫生—呼吸系统]