全身麻醉药物对微生物-肠-脑轴影响的研究进展  

Research progress on the effects of general anesthetics on the microbiota-gut-brain axis

作　　者：谷茜 舒进军[1] GU Qian;SHU Jinjun(Department of Anesthesiology,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,China)

机构地区：[1]四川省肿瘤临床医学研究中心,四川省肿瘤医院研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院麻醉科,四川省成都市610041

出　　处：《临床麻醉学杂志》2024年第10期1085-1088,共4页Journal of Clinical Anesthesiology

基　　金：四川省保健委员会科研项目(川干研2023-805)。

摘　　要：肠道微生物与宿主之间形成了复杂的共生关系,并且肠道微生物与大脑之间存在着双向交流的通路,即“微生物-肠-脑轴”。研究表明,全身麻醉药物与大脑之间可以通过微生物-肠-脑轴进行复杂的双向交流,全身麻醉药物可以改变肠道微生物群的组成和代谢。本文就常见的全身麻醉药物对微生物-肠-脑轴的影响及其机制进行综述,以期为开展麻醉与微生物-肠-脑轴的相关研究提供参考。There is a complex symbiotic relationship between gut microbiota and the host,and a bidirectional communication pathway exists between gut microbiota and the brain,known as the“microbiota-gut-brain axis”.Research has found that general anesthetics and the brain can engage in complex two-way communication through the microbiota-gut-brain axis.General anesthetics can alter the composition and metabolism of gut microbiota.This article reviews the effects of common general anesthetics on the microbiota-gut-brain axis and their mechanisms,with the aim of providing reference for the related research on anesthesia and the microbiota-gut-brain axis.

关 键 词：微生物-肠-脑轴 肠道微生物 全身麻醉药物 

分 类 号：R614[医药卫生—麻醉学]