白芍总苷对幼年类风湿性关节炎患儿血清B细胞激活因子的影响  

Effect of total glucosides of paeonia on serum B cell activating factor in children with juvenile rheumatoid arthritis

作　　者：吕美玲[1] 王信芳[1] 陈钊扬 张琳[1] LYU Meiling;WANG Xinfang;CHEN Zhaoyang;ZHANG Lin(Department of Paediatrics,Zhongshan Hospital of Traditional Chinese Medicine,Guangdong,Zhongshan 528400,China)

机构地区：[1]广东省中山市中医院儿科,广东中山528400

出　　处：《中国医药科学》2024年第18期77-80,共4页China Medicine And Pharmacy

基　　金：广东省中山市医学科研项目(2021A020813)。

摘　　要：目的探讨白芍总苷对幼年类风湿性关节炎患儿的临床疗效及对血清B细胞激活因子的影响。方法选取中山市中医院儿科2019年8月至2021年8月收治的40例幼年类风湿性关节炎患儿为研究对象,按照随机数表法将其分为对照组(20例)与治疗组(20例)。对照组仅接受口服布洛芬缓释混悬剂,治疗组在口服布洛芬缓释混悬剂基础上同时加白芍总苷胶囊治疗。两组均进行12周持续治疗。观察两组治疗后关节发热、肿胀、晨僵等症状的消失时间,红细胞沉降率、类风湿性因子、B细胞激活因子及C反应蛋白的变化。结果治疗后,治疗组总有效率高于对照组,治疗组的关节发热、肿胀及晨僵症状消失时间均短于对照组,且红细胞沉降率、类风湿性因子、C反应蛋白水平及B细胞激活因子均低于对照组,差异有统计学意义(P<0.05);两组患儿不良反总发生率比较,差异无统计学意义(P>0.05)。结论白芍总苷用于治疗幼年类风湿性关节炎患儿,其临床疗效显著,可抑制B细胞激活因子表达,降低患儿红细胞沉降率水平及C反应蛋白水平,改善患儿类风湿关节炎的临床症状,且安全系数良好,值得临床推广使用。Objective To explore the clinical efficacy of total glucosides of paeonia on children with juvenile rheumatoid arthritis and its impact on serum B cell activating factors.Methods A total of 40 children with rheumatoid arthritis admitted to the Department of Paediatrics,Zhongshan Hospital of Traditional Chinese Medicine from August 2019 to August 2021 were selected as the study subjects.They were randomly divided into a control group(20 cases)and a treatment group(20 cases)using a random number table method.The control group only received oral ibuprofen sustained-release suspension,while the treatment group received both oral ibuprofen sustained-release suspension and total glucosides of paeonia capsules for treatment.Both groups received continuous treatment for 12 weeks.The disappearance time of joint fever,swelling,morning stiffness and other symptoms,the changes of erythrocyte sedimentation rate,rheumatoid factors,B cell activating factor and C-reactive protein were observed in the two groups after treatment.Results After treatment,the total effective rate of the treatment group was higher than that of the control group,and the disappearance time of joint fever,swelling,and morning stiffness symptoms in the treatment group was shorter than that of the control group.In addition,the erythrocyte sedimentation rate,rheumatoid factors,C-reactive protein levels,and B cell activating factor were all lower than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference i n the overall incidence ofadverse reactions between the two groups of children(P>0.05).Conclusion The total glucosides of paeonia are used to treat children with juvenile rheumatoid arthritis,and their clinical efficacy is significant.They can inhibit the expression of B cell activating factors,reduce the levels of erythrocyte sedimentation rate and C-reactive protein in children,improve the clinical symptoms of rheumatoid arthritis in children,and have a good safety factor.The

关 键 词：白芍总苷 类风湿关节炎 患儿 临床疗效 

分 类 号：R272[医药卫生—中医儿科学]