减重后为何会出现体重反弹?  

Why does weight regain occur after weight loss?

作　　者：张群 谭莺[2] 朱延华[2] 陈燕铭[2,3] ZHANG Qun;TAN Ying;ZHU Yanhua;CHEN Yanming(Chaozhou Central Hospital,Chaozhou 521000,China;Department of Endocrinology and Metabolism,the Third Affiliated Hospital of Sun Yat-sen University,Guangdong Provincial Key Laboratory of Diabetes Prevention and Treatment,Guangzhou 510630,China;Clinical Immunology Center,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]潮州市中心医院,广东潮州521000 [2]中山大学附属第三医院内分泌与代谢病学科广东省糖尿病防治重点实验室,广东广州510630 [3]中山大学附属第三医院临床免疫中心,广东广州510630

出　　处：《新医学》2024年第9期677-684,共8页Journal of New Medicine

基　　金：国家自然科学基金(82270886);中山大学临床医学研究5010计划(2023006)。

摘　　要：肥胖作为一种全球性的健康问题,其治疗及管理挑战重重,尤其是体重(体质量)反弹现象,它不仅削弱了减重效果,还可能对患者的身心健康造成进一步影响。文章深入探讨了肥胖治疗中的体质量反弹问题,分析了体质量反弹的定义、普遍性及其对健康的影响。从体质量调定点理论、代谢适应、免疫细胞表型变化、脂质代谢以及食欲调控等方面,阐释了体质量反弹的生物学机制。提出了综合管理策略,包括生活方式调整、持续药物治疗、手术干预和多学科协作,以期实现肥胖患者长期的体质量管理。研究强调了体质量管理的持续性和个体化,为临床实践提供了科学指导。Obesity,as a global health issue,presents significant challenges in its treatment and management,particularly the phenomenon of weight regain.This not only undermines the effectiveness of weight loss efforts but may also have further impacts on the physical and mental health of patients.This article delves into the issue of weight regain during the treatment of obesity,analyzing its definition,prevalence,and health implications.It elucidates the biological mechanisms of weight regain from aspects such as the body weight set-point theory,metabolic adaptation,immune cell phenotypic changes,lipid metabolism,and appetite regulation.A comprehensive management strategy is proposed,including lifestyle adjustments,continuous pharmacological treatment,surgical intervention,and multidisciplinary collaboration,aiming to achieve long-term weight control in obese patients.The study emphasizes the continuity and individualization of weight management,providing scientific guidance for clinical practice.

关 键 词：肥胖 体质量反弹 体质量管理 

分 类 号：R589.2[医药卫生—内分泌]