A型肉毒毒素在玫瑰痤疮治疗中的应用:现状、问题与挑战  

Botulinum Toxin A in the Treatment of Rosacea:Current Situations,Problems and Challenges

作　　者：李祥子 朱雅倩 赖维[2] LI Xiangzi;ZHU Yaqian;LAI Wei(Shenzhen Center for Chronic Disease Control,Shenzhen Insititute of Dermatology,Shenzhen 518020,China;The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630,China)

机构地区：[1]深圳市慢性病防治中心,深圳市皮肤病防治研究所,广东深圳518020 [2]中山大学附属第三医院,广东广州510630

出　　处：《皮肤科学通报》2024年第4期366-371,共6页Dermatology Bulletin

基　　金：深圳市卫生经济学会科研基金(202432)。

摘　　要：玫瑰痤疮是一种好发于面中部的慢性炎症性疾病,发病机制尚未明确,面部持续性红斑及阵发性潮红是其治疗难点。A型肉毒毒素在临床上广泛应用于皮肤美容,近年来不少研究证实还可以应用于玫瑰痤疮的治疗,为临床提供了一种新的治疗选择。但A型肉毒毒素治疗玫瑰痤疮的机制、适应症、具体的治疗方案以及疗效、安全性、联合治疗方案等仍存在诸多问题,尚无统一意见。本文综述了A型肉毒毒素治疗玫瑰痤疮的最新研究进展,探讨目前存在的问题和挑战,以期为未来进一步寻找更科学、更规范的治疗方案,进行更多高质量的研究指明方向。Rosacea is a chronic inflammatory disease that occurs in the midface,the pathogenesis of which remains unknown.Persistent facial erythema and episodic facial flushes are challenging problem to treat.Botulinum toxin A applied extensively clinically in cosmetic dermatology.Recent studies have confirmed that it could be applied to the rosacea,which provide a new option for clinicians.However,there is no consensus on the mechanisms,indications,specific treatment options,efficacy,safety and the combination therapy regimens of botulinum toxin A treatment in rosacea.In this review,we update the recent progress on botulinum toxin A in the treatment of rosacea and explore the existing problems and challenges.The search for a more ideal and high-quality regimen yet continued.

关 键 词：A型肉毒毒素 玫瑰痤疮 应用 问题与挑战 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]