A型肉毒毒素改善炎症后色素沉着(PIH)的研究  

Research of Botulinum Toxin Type A on Improving Post-Inflammatory Pigmentation(PIH)

作　　者：汪杨美惠 杨斌 刘振锋 WANG Yangmeihui;YANG Bin;LIU Zhenfeng(Southern Medical University Dermatology Hospital,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤科学通报》2024年第4期403-406,共4页Dermatology Bulletin

摘　　要：炎症后色素沉着(post-inflammatory hyperpigmentation,PIH)是皮肤在发生炎症或损伤后,受累区域出现肤色异常加深的一种常见的皮肤问题。目前针对PIH有多种治疗方法,如外用或口服药物、化学换肤、光电治疗等,但疗效有限。近期研究发现,许多接受肉毒素注射治疗的患者在面部皱纹改善的同时,皮肤亮度增加、肤色变浅,但具体机制不明。本文综述了A型肉毒素在治疗PIH方面的最新研究进展,探讨其可能的作用机制、临床疗效及未来研究方向,为PIH患者提供新的治疗选择。Post-inflammatory hyperpigmentation(PIH)is a common skin issue characterized by abnormal darkening of the skin in areas damaged by inflammation or injury.Despite various PIH treatment methods,such as topical or oral medications,chemical peels,and phototherapy,the efficacy remains limited.Recent studies have found that many patients undergoing botulinum toxin injections for facial wrinkles experienced increased skin brightness and lightening of skin tone alongside wrinkle improvement,though the specific mechanism is unclear.This article reviews the recent research progress of type A botulinum toxin in treating PIH,exploring its potential mechanisms of action,clinical efficacy,and future research directions to provid new treatment options for PIH patients.

关 键 词：炎症后色素沉着 A型肉毒毒素 炎症 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]