扁柏酚及其组合物抑制马拉色菌性能研究  

Study on the Inhibitory Activities of Hinokitiol and Its Combinations Against Malassezia

作　　者：闫永涛 郭惠珊 曹菲 甘礼社 徐学涛 李晓敏 YAN Yongtao;GUO Huishan;CAO Fei;GAN Lishe;XU Xuetao;LI Xiaomin(Perfect(Guangdong)Commodity Co.,Ltd.,Zhongshan,Guangdong 528400,China;School of Pharmacy and Food Engineering,Wuyi University,Jiangmen,Guangdong 529020,China)

机构地区：[1]完美(广东)日用品有限公司,广东中山528400 [2]五邑大学药学与食品工程学院,广东江门529020

出　　处：《中国洗涤用品工业》2024年第9期54-61,共8页China Cleaning Industry

摘　　要：探究了扁柏酚及其组合物抑制马拉色菌的性能。扁柏酚对糠秕马拉色菌的MIC为3.91μg/mL;Fe^(2+)可以使扁柏酚失活,Cu^(2+)降低了扁柏酚的活性,而金属螯合剂EDTA二钠可以增强扁柏酚的活性;联合药敏实验结果显示,γ-十一内酯、γ-壬内酯、硫辛酸分别对扁柏酚在抑制糠秕马拉色菌上起到协同、相加、无关作用。含有扁柏酚、EDTA二钠、γ-十一内酯、γ-壬内酯、硫辛酸的组合物对糠秕马拉色菌、球型马拉色菌、斯洛菲马拉色菌、合轴马拉色菌、钝型马拉色菌共5种马拉色菌具有优异的抑制能力。该研究为扁柏酚及其组合物在抑制马拉色菌领域的应用提供了依据。The inhibitory properties of hinokitiol and its combinations on Malassezia were investigated.The MIC of hinokitiol on Malassezia furfurwas 3.91μg/mL.Fe^(2+)could inactivate hinokitiol,while EDTA disodium enhanced the activity of hinokitiol.γ-undecalactone,γ-nonalactone,and thioctic acid played a synergistic,additive,and irrelevant role combined with hinokitiol against M.furfur,respectively.The combination containing hinokitiol,EDTA disodium,γ-undecalactone,γ-nonolactone and thioctic acid had excellent inhibitory ability against M.furfur,M.globosa,M.sloffii,M.sympodialis and M.obtusa.This study provides a solid basis for the application of hinokitiol and its combinations in the field of Malassezia inhibition.

关 键 词：马拉色菌 扁柏酚 体外药敏实验 

分 类 号：TQ658[化学工程—精细化工]