血清PCT、IL-6在细菌感染患儿中的诊断价值  

The Diagnostic Value of Serum PCT and IL-6 in Children with Bacterial Infections

作　　者：武志芳[1] 张刚强[1] 韩春滔 WU Zhifang;ZHANG Gangqiang;HAN Chuntao(Laboratory Department of Anyang Traditional Chinese Medicine Hospital,Anyang,Henan 455000,China)

机构地区：[1]安阳市中医院检验科,河南安阳455000

出　　处：《生物医学工程学进展》2024年第3期228-233,共6页Progress in Biomedical Engineering

摘　　要：目的探讨血清降钙素原(PCT)和白介素-6(IL-6)在细菌感染患儿诊断中的价值。方法选取2021年1月1日至2023年7月1日安阳市中医院诊治的125例疑似细菌感染患儿为研究对象,根据细菌学培养结果将其分为阳性组(n=67)和阴性组(n=58),采用免疫荧光法、电化学发光法分别检测两组的PCT、IL-6,比较两组在不同感染菌类型下、不同时间点的PCT、IL-6水平,并绘制ROC曲线,比较PCT、IL-6检测的诊断效能。结果入院时,阳性组PCT、IL-6水平高于阴性组,差异有统计学意义(t分别为6.512、3.861,P<0.001),而在治疗7天后,阳性组PCT、IL-6水平均较入院时显著降低,且逐渐接近阴性组,差异有统计学意义(t分别为22.634、13.406,P<0.001);革兰阴性菌PCT、IL-6水平明显高于革兰阳性菌,差异有统计学意义(t分别为3.125、2.521,P<0.001);ROC曲线分析结果显示,PCT对细菌感染患儿的诊断敏感度、特异度分别为71.64%、81.03%,AUC=0.800(0.719~0.866),IL-6对细菌感染患儿的诊断敏感度、特异度分别为68.66%、65.52%,AUC=0.687(0.598~0.767)。结论PCT、IL-6在细菌感染诊断中均具有较高的诊断价值,操作方法简便可行,可有效鉴别细菌感染患儿的感染类型,能为诊断提供一定的实验室依据。Objective To explore the diagnostic value of serum procalcitonin(PCT)and interleukin-6(IL-6)in children with bacterial infections.Methods A total of 125 children with suspected bacterial infection from January 1,2021 to July 1,2023 were selected as the research objects.According to the results of bacteriological culture,they were divided into positive group(n=67)and negative group(n=58).The levels of PCT and IL-6 in the two groups were detected by immunofluorescence method and electrochemiluminescence method respectively.The levels of PCT and IL-6 in the two groups were compared under different types of infected bacteria and at different time points,and ROC curves were drawn.Result At admission,the levels of PCT and IL-6 in the positive group were higher than those in the negative group,and the difference was statistically significant(t=6.512,3.861,both P<0.001),and after 7 days of treatment,the levels of PCT and IL-6 in the positive group were significantly reduced compared to those at admission and gradually approached the negative group,the difference was statistically significant(t=22.634,13.406,both P<0.001);The levels of PCT and IL-6 was significantly higher than those of Gram positive bacteria,and the difference in bacteria was statistically significant(t=3.125,2.521,both P<0.001);those ROC curve analysis showed that the diagnostic specificity and sensitivity of PCT for children with bacterial infections were 71.64%and 81.03%respectively,AUC=0.800(0.719~0.866),and the diagnostic specificity and sensitivity of IL-6 for children with bacterial infections were 65.52%and 68.66%respectively,AUC=0.687(0.598~0.767).Conclusion PCT and IL-6 have high diagnostic value in the diagnosis of bacterial infections,and the operation method is simple and feasible,which can effectively distinguish the type of infection in children with bacterial infections and provide a certain laboratory basis for diagnosis.

关 键 词：降钙素原 白介素-6 细菌感染 诊断价值 

分 类 号：R722.13[医药卫生—儿科]