通调任督针刺法联合孟鲁司特钠治疗咳嗽变异性哮喘  

Clinical efficacy of regulating Ren and Du channel acupuncture therapy combined with Montelukast sodium in the treatment of cough variant asthma

作　　者：阚书慧 李朋成 孔连委 白丽 张丹 KAN Shuhui;LI Pengcheng;KONG Lianwei;BAI Li;ZHANG Dan(Department of Lung Diseases,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150036,China;The Third Hospital of Heilongjiang,Harbin 150081,China;Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150036,China;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;The Second Department of Acupuncture and Moxibustion,Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150066,China)

机构地区：[1]黑龙江中医药大学附属第二医院肺病科,哈尔滨150036 [2]黑龙江省第三医院,哈尔滨150081 [3]黑龙江省中医药科学院,哈尔滨150036 [4]黑龙江中医药大学附属第一医院,哈尔滨150040 [5]黑龙江中医药大学附属第二医院哈南分院针灸二科,哈尔滨150066

出　　处：《长春中医药大学学报》2024年第10期1111-1115,共5页Journal of Changchun University of Chinese Medicine

基　　金：黑龙江省中医药科研项目(ZHY2023-026)。

摘　　要：目的探讨通调任督针刺法联合孟鲁司特钠治疗咳嗽变异性哮喘患者临床疗效及对血清Toll样受体4(TLR4)、嗜酸性粒细胞趋化因子(Eotaxin)、可溶性生长刺激表达基因2(sST-2)影响。方法选择94例咳嗽变异性哮喘患者,随机分为对照组与观察组,各47例。对照组予孟鲁司特钠治疗,观察组在对照组基础上采用通调任督针刺法治疗,2组均连续治疗8周。比较2组临床疗效、肺功能、免疫功能、炎症因子、血清TLR4、Eotaxin、sST-2水平及不良反应发生情况。结果观察组临床疗效总有效率(93.62%,44/47)优于对照组(76.60%,36/47)(P<0.05);治疗后,2组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均高于治疗前,呼气峰值流量(PEF)变异率低于治疗前,且观察组优于对照组(P<0.05);治疗后,2组CD3^(+)、CD4^(+)水平高于治疗前,CD8^(+)低于治疗前,且观察组优于对照组(P<0.05);治疗后,2组白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、肿瘤坏死因子-a(TNF-a)水平低于治疗前,且观察组低于对照组(P<0.05);治疗后,2组TLR4、Eotaxin、sST-2水平低于治疗前,且观察组低于对照组(P<0.05)。结论通调任督针刺法联合孟鲁司特钠治疗咳嗽变异性哮喘,可以显著改善肺功能,提升免疫力,抑制炎症反应,降低血清TLR4、Eotaxin、sST-2水平,值得临床推广应用。Objective To ecplore the clinical efficacy of regulating Ren and Du channel acupuncture therapy combined with Montelukast sodium in the treatment of cough variant asthma and its effects on the levels of serum Toll-like receptor 4(TLR4),eosinophilic chemotactic factor(Eotaxin)and soluble growth stimulation expression gene 2(sST-2).Methods A total of 94 patients with cough variant asthma were selected and randomly divided into the control group and the observation group,with 47 cases in each group.The control group received treatment with Montelukast sodium,while the observation group received regulating Ren and Du channel acupuncture therapy on the basis of the treatment of the control group.Both groups were treated continously for 8 weeks.The clinical efficacy,pulmonary function,immune function,levels of inflammatory factors,serum levels of TLR4,Eotaxin and sST-2,and the occurrence of adverse reactions between two groups were compared.Results The total clinical effective rate in the observation group(93.62%,44/47)was higher than that in the control group(76.60%,36/47)(P<0.05).After treatment,the forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and FEV1/FVC of both groups were higher than those before treatment,and the peak expiratory flow(PEF)mutation rate was lower than that before treatment,and the observation group was better than the control group(P<0.05).After treatment,the levels of CD3^(+)and CD4^(+)in both groups were higher than those before treatment,and the level of CD8^(+)was lower than that before treatment,and the observation group was better than the control group(P<0.05).After treatment,the levels of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the levels of TLR4,Eotaxin,and sST-2 in both groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).Conclusion Regulati

关 键 词：通调任督针刺法 孟鲁司特钠 咳嗽变异性哮喘 Toll样受体4 嗜酸性粒细胞趋化因子 可溶性生长刺激表达基因2 

分 类 号：R256.1[医药卫生—中医内科学]