滋阴运脾法治疗干燥综合征  

Clinical efficacy of nourishing yin and transporting the spleen in the treatment of Sjogren's Syndrome

作　　者：秦董怀[1] 顾振宁 薛益兴[1] QIN Donghuai;GU Zhenning;XUE Yixing(Department of Rheumatology and Immunology,Jiangyin Hospital of Traditional Chinese Medicine,Wuxi 214400,China)

机构地区：[1]江阴市中医院风湿免疫科,江苏无锡214400

出　　处：《长春中医药大学学报》2024年第10期1121-1125,共5页Journal of Changchun University of Chinese Medicine

基　　金：江苏省自然科学基金面上项目(BK20201118)。

摘　　要：目的观察滋阴运脾法联合西医治疗干燥综合征的临床疗效与对患者炎症因子及免疫功能的影响。方法选择干燥综合征患者80例,采用随机数表法分为对照组与观察组,各40例。对照组给予西医治疗,观察组在西医基础上联合滋阴运脾方中药治疗。检测2组外分泌腺指标、免疫球蛋白、补体及红细胞沉降率(ESR)、干扰素-α(IFN-α)、B细胞刺激因子(BAFF)蛋白水平,评估2组干燥综合征疾病自我感受(ESSPRI)评分、中医证候积分、干燥综合征疾病活动指数(ESSDAI)评分变化。结果与治疗前比较,2组治疗12周后唾液流量、自然唾液流率及左侧/右侧泪液分泌明显升高,观察组治疗12周后相关外分泌腺指标均高于对照组(P<0.05)。IgA、IgM、IgG及ESR、IFN-α、BAFF蛋白明显下降,观察组治疗12周后除IgM外其他指标均低于对照组(P<0.05)。2组治疗12周后C3、C4明显升高,观察组治疗12周后C3高于对照组(P<0.05)。2组治疗12周后ESSPRI评分、中医证候积分、ESSDAI评分明显下降,且观察组低于对照组(P<0.05)。结论滋阴运脾法联合西医治疗干燥综合征,可减轻患者症状,抑制炎症因子表达,改善免疫功能和外分泌腺功能。Objective To observe the clinical efficacy of nourishing yin and transporting the spleen combined with Western medicine in the treatment of Sjogren's Syndrome and its influence on inflammatory factors and immune function of patients.Methods 80 patients with Sjogren's Syndrome were selected and divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group was treated with Western medicine,while the observation group was treated with nourishing yin and transporting the spleen formula and traditional Chinese medicine on the basis of the treatment of Western medicine.The levels of indexes of exocrine gland,immunoglobulin,complement,interferon-α(IFN-α)and B cell activating factor of the TNF family(BAFF),and erythrocyte sedimentation rate(ESR)were detected in two groups.The changes in Essential Self-Sensory Perception Rating Index(ESSPRI),traditional Chinese medicine(TCM)syndrome score,and European League Against Rheumatism Sjogren's Syndrome Disease Activity Index(ESSDAI)of two groups were evaluated.Results Compared with before treatment,the salivary flow rate,unstimulated salivary flow rate and left-side tear/right-side tear secretion in two groups were significantly increased after 12 weeks of treatment,and the levels of relevant exocrine gland indexes in the observation group were higher than those in the control group after 12 weeks of treatment(P<0.05).Compared with before treatment,the levels of IgA,IgM,IgG and IFN-α,and ESR in two groups significantly decreased.After 12 weeks of treatment,except for IgM level,the levels of all other indexes in the observation group were lower than those in the control group(P<0.05).After 12 weeks of treatment,the levels of C3 and C4 significantly increased in two groups.After 12 weeks of treatment,the C3 level in the observation group was higher than that in the control group(P<0.05).After 12 weeks of treatment,the ESSRI score,TCM syndrome score,and ESSDAI score significantly decreased in both g

关 键 词：滋阴运脾法 干燥综合征 免疫功能 炎症因子 外分泌腺功能 

分 类 号：R255[医药卫生—中医内科学]