甲状腺癌风险与血浆25-羟基维生素D和维生素D结合蛋白的关系  

Relationship between thyroid cancer risk and plasma 25 hydroxyvitamin D and vitamin D binding proteins

作　　者：关昊[1] 李宗禹 赖婧玥 马建仓[1] GUAN Hao;LI Zongyu;LAI Jingyue;MA Jiancang(Department of Vascular Surgery,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院血管外科,西安710004

出　　处：《长春中医药大学学报》2024年第10期1135-1138,共4页Journal of Changchun University of Chinese Medicine

基　　金：陕西省自然科学基础研究计划项目(2020J9-555)。

摘　　要：目的分析甲状腺癌风险与血浆25-羟基维生素D[25(OH)D]和维生素D结合蛋白(VDBP)的关系。方法选择我院2022年1月-2023年9月诊治的甲状腺癌患者102例为恶性组,并选择同期诊治的良性甲状腺结节患者102例为良性组,分析发生甲状腺癌风险的危险因素,以及血浆25(OH)D、VDBP对甲状腺癌的诊断价值。结果与良性组比较,恶性组血浆25(OH)D、VDBP更低(P<0.05),恶性组血清游离甲状腺素(FT4)、尿碘/肌酐值更高(P<0.05),恶性组其余因素差异无统计学意义(P>0.05)。以组别为因变量,以单因素分析中差异有统计学意义的因素为自变量,经二元Logisic回归分析,高25(OH)D、高VDBP是发生甲状腺癌风险的保护因素(P<0.05),高FT4、高尿碘/肌酐值是发生甲状腺癌风险的危险因素(P<0.05)。ROC曲线分析得出,血浆25(OH)D、VDBP、二者联合诊断甲状腺癌的AUC分别为0.840、0.811、0.862,敏感度分别为91.2%、93.1%、87.3%,特异度分别为66.7%、60.8%、86.3%。结论发生甲状腺癌风险和血浆25(OH)D、VDBP降低,血清FT4、尿碘/肌酐值升高有关,血浆25(OH)D、VDBP联合对甲状腺癌具有较高的诊断价值。Objective To analyze the relationship between the risk of thyroid cancer and plasma levels of 25 hydroxyvitamin D[25(OH)D]and vitamin D binding protein(VDBP).Methods 102 patients with thyroid cancer diagnosed and treated in the Second Affiliated Hospital of Xi'an Jiaotong University from January 2022 to September 2023 were selected as the malignant group,and 102 patients with benign thyroid nodules diagnosed and treated during the same period were selected as the benign group.The risk factors for thyroid cancer and the diagnostic value of plasma 25(OH)D and VDBP for thyroid cancer were analyzed.Results Compared with the benign group,the levels of plasma 25(OH)D and VDBP were lower in the malignant group(P<0.05),the serum free thyroxine 4(FT4)level and urinary iodine/creatinine value were higher in the malignant group(P<0.05),and there was no statistically significant difference in other factors in the malignant group(P>0.05).Using group as the dependent variable,and factors with statistically significant differences in univariate analysis as the independent variable,binary Logistic regression analysis showed that the levels of high 25(OH)D and high VDBP were protective factors for thyroid cancer(P<0.05),while high FT4 level and high urinary iodine/creatinine value were risk factors for thyroid cancer(P<0.05).Rreceiver operating characteristic curve(ROC curve)analysis showed that area under the curve(AUC)of plasma 25(OH)D,VDBP,and their combination for diagnosing thyroid cancer was 0.840,0.811,and 0.862,respectively,the sensitivity was 91.2%,93.1%,and 87.3%respectively,and the specificity was 66.7%,60.8%,and 86.3%,respectively.Conclusion The risk of thyroid cancer is related to the decrease in plasma 25(OH)D and VDBP levels,as well as the increase in serum FT4 level and urine iodine/creatinine value.The combination of plasma 25(OH)D and VDBP has high diagnostic value for thyroid cancer.

关 键 词：甲状腺癌 甲状腺结节 25-羟基维生素D 维生素D结合蛋白 

分 类 号：R581[医药卫生—内分泌]