支气管哮喘患儿持续性气流受限的影响因素分析  

Analysis of influencing factors of asthma children with persistent airflow limitation

作　　者：牟京辉[1] 刘帅 陈韦 邵明军[1] 沙莉[1] 刘传合[1] Mou Jinghui;Liu Shuai;Chen Wei;Shao Mingjun;Sha Li;Liu Chuanhe(Department of Allergy,Children's Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院变态反应科,北京100020

出　　处：《北京医学》2024年第7期577-581,共5页Beijing Medical Journal

摘　　要：目的探讨支气管哮喘患儿持续性气流受限(persistent airflow limitation,PAL)的影响因素。方法选取2021年1—12月首都儿科研究所附属儿童医院就诊的5~17岁PAL哮喘患儿(病例组)和同期就诊的非PAL哮喘患儿(对照组),每组50例。采集两组患儿临床资料,比较个人史、哮喘发作、过敏状况、呼吸道感染、肺功能水平等,采用多因素logistic回归方程分析PAL的影响因素。结果100例患儿中,男78例、女22例;年龄(9.5±2.2)岁。多因素logistic回归分析结果显示,既往肺炎史(OR=5.863,95%CI:2.295~14.975,P<0.01)、哮喘最严重一年发作次数越高(OR=1.599,95%CI:1.079~18.436,P<0.01)的患儿越容易发生PAL。结论哮喘患儿发生PAL起病早,肺炎史、哮喘频繁发作是患儿发生PAL的危险因素。应重视预防感染、减少呼吸道感染次数,合理用药,控制支气管哮喘发作,以减少PAL的发生。Objective To explore the influencing factors of persistent airflow limitation(PAL)in asthmatic children.Methods Asthmatic children who visited the Children's Hospital Affiliated to Capital Institute of Pediatrics from January to December 2021 were divided into case group(children with PAL)and control group(children without PAL),50 cases in each group.The clinical data of the two groups were collected,and the personal history,asthma attack,allergic status,respiratory tract infection,and pulmonary function levels of the two groups were compared.Multivariate regression analysis was used to analyze the influencing factors of PAL.Results Among the 100 children,there were 78 males and 22 females,the mean age was(9.5±2.2)years.Multivariate regression analysis showed that children with the history of pneumonia(OR=5.863,95%CI:2.295-14.975,P<0.01)and frequent attacks of asthma(OR=1.599,95%CI:1.079-18.436,P<0.01)were more likely to have PAL.Conclusions PAL occurs early in asthmatic children,and the history of pneumonia,frequent attacks of asthma are the independent influencing factors of PAL in asthmatic children.In order to decrease the incidence of PAL,attention should be paid to prevent infection,reduce the incidence of respiratory infection and treat properly to control asthma.

关 键 词：支气管哮喘 肺炎 持续性气流受限 影响因素 儿童 

分 类 号：R725.6[医药卫生—儿科]