Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study  

作　　者：Yanting Wen Yijie Huang Lin Huang Dan Wu Renbin Zhong Shixie Jiang Yudi Zhang Ting Liu Xiaotian Liu Huabei Jiang 

机构地区：[1]Department of Ultrasound,Chengdu Fifth People's Hospital Chengdu 611137,P.R.China [2]School of Computer Science and Technology Chongqing University of Posts and Telecommunications Chongqing 400065,P.R.China [3]School of Electronic Science and Engineering University of Electronic Science and Technology Chengdu 611731,P.R.China [4]Department of Psychiatry University of Florida College of Medicine,Gainesville,FL 32610,USA [5]Department of Medical Engineering University of South Florida,Tampa 33620,USA

出　　处：《Journal of Innovative Optical Health Sciences》2024年第6期15-28,共14页创新光学健康科学杂志（英文）

基　　金：supported by the program of Chengdu Fifth people's hospital Fund,No.KYJJ 2021-29;the Xinglin Scholars research program,No.YYZX2021037;the Chengdu Medical Research Project,Nos.2022055 and 2023022,Chongqing Education Commission,Youth Fund(No.KJQN202000607);Chongqing postdoctoral research project(special funding project,No.2021XM3040).

摘　　要：Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and practicality.This pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the US for the multiparametric quantitative assessment of human nail.The study involved a small cohort offive healthy volunteers who underwent PAT/US imaging for acquiring the nail unit data.The PAT/US dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail bed.Moreover,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail bed.The quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological conditions.This pilot study highlights the potential of PAT/US dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.

关 键 词：NAIL photoacoustic tomography ULTRASOUND MULTI-MODALITY quantitative parameter 

分 类 号：R445.1[医药卫生—影像医学与核医学]