基于“正邪理论”探讨心力衰竭心肌能量代谢及中药干预机制  

Exploring myocardial energy metabolism in heart failure and the mechanism of Chinese medicine intervention based on the“theory of antipathogenic qi and pathogenic factors”

作　　者：袁惠 魏佳明 施敏 郭志华 YUAN Hui;WEI Jiaming;SHI Min;GUO Zhihua(The First Clinical College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of Intelligent Diagnosis of Chronic Diseases by Traditional Chinese Medicine and Treatment of Future Diseases,Hunan University of Chinese Medicine,Changsha 410208,China;Postgraduate Joint Training Base of Internet+TCM Diagnosis and Treatment of Chronic Diseases and Intelligent Application of Health Care,Changsha 410208,China)

机构地区：[1]湖南中医药大学第一中医临床学院,长沙410208 [2]湖南中医药大学慢病中医智能诊断与治未病湖南省普通高等学校重点实验室,长沙410208 [3]互联网+慢病中医诊治与养生智能化应用研究生联合培养基地,长沙410208

出　　处：《天津中医药》2024年第10期1347-1353,共7页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82174343,81673955);湖南省重点科研计划项目(2022SK2012);湖南中医药大学“一方”研究生创新项目(2023YF10);湖南省研究生科研创新项目(QL20230197,CX20230832)。

摘　　要：心肌能量代谢障碍是心力衰竭病变的重要特征,改善心肌能量代谢已成为防治心力衰竭的关键手段。基于病证结合、多靶点综合调控的辨治理念,中医药在改善心肌能量代谢方面显示出独特优势。心力衰竭的发生发展源于正邪相争,乃正虚邪实之证。心肌能量代谢障碍是正气亏虚的微观表现。基于“正邪理论”,以“扶正祛邪”为原则,立法选方改善心肌能量代谢,对防治心力衰竭具有重要意义。Myocardial energy metabolism disorder is an important feature of heart failure,improving myocardial energy metabolism has become a crucial means of prevention and treatment of heart failure.Traditional Chinese medicine has shown unique advantages in terms of improving myocardial energy metabolism by virtue of its concept of syndrome differentiation and multi-target comprehensive regulation.The occurrence and development of heart failure stem from the struggle between antipathogenic qi and pathogenic factors and the syndrome type of heart failure is healthy qi deficiency and pathogenic qi excess.Dysfunction of myocardial energy metabolism can be regarded microscopically as a manifestation of healthy qi deficiency.Therefore,based on the “theory of antipathogenic qi and pathogenic factors” and the basic principle of “reinforce healthy qi to eliminate pathogenic factors”,it's of great significance for treating heart failure determining methods and selecting prescriptions to improve myocardial energy metabolism.

关 键 词：心力衰竭 正邪理论 心肌能量代谢 中药干预 

分 类 号：R541[医药卫生—心血管疾病]