霜脲氰的合成工艺改进  

Improvement for the synthesis process of cymoxanil

作　　者：徐宁 李林虎 许宜伟 葛凤敏 XU Ning;LI Linhu;XU Yiwei;GE Fengmin(Limin Group Co.,Ltd.,Jiangsu Xuzhou221400,China)

机构地区：[1]利民控股集团股份有限公司,江苏徐州221400

出　　处：《现代农药》2024年第5期56-58,共3页MODERN AGROCHEMICALS

摘　　要：针对目前霜脲氰合成工艺产品收率低、“三废”量大、安全性低等问题,开发了一种改进的生产工艺。以1-氰乙酰基-3-乙基脲为原料,经与亚硝酸异丙酯肟化反应,然后在催化剂存在下,与氯甲烷进行甲基化反应,得到霜脲氰。在优化的工艺条件下,产品收率在95%以上,产品质量分数可达99%。In view of the problems of low yield,large amounts of wastes and low safety,an improved synthesis process was developed.The target product cymoxanil was obtained by two steps,1-cyanoacetyl-3-ethyl urea reacted with isopropyl nitrite via oximation reaction,and then reacted with methyl chloride via methylation reaction in the presence of catalyst.The yield of the product was over 95%and the purity of the product was 99%under the optimized process conditions.

关 键 词：霜脲氰 亚硝酸异丙酯 氯甲烷 甲基化反应 工艺改进 

分 类 号：TQ455.4[化学工程—农药化工]