自然杀伤(NK)细胞与2019冠状病毒病(COVID-19)发生发展的研究进展  

Research progress of natural killer(NK)cells and the development of coronavirus disease 2019(COVID-19)

作　　者：陈娟 周永学[1,2] 包晟川 陈婷 李京涛 魏海梁 闫曙光 CHEN Juan;ZHOU Yongxue;BAO Shengchuan;CHEN Ting;LI Jingtao;WEI Hailiang;YAN Shuguang(College of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046;Shaanxi Provincial Key Laboratory of Gastrointestinal Diseases,Xianyang 712046;Department of Infectious Disease,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China;Department of General Surgery,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]陕西省胃肠病证方药重点研究室,陕西咸阳712046 [3]陕西中医药大学附属医院感染科,陕西咸阳712000 [4]陕西中医药大学附属医院普外科,陕西咸阳712000

出　　处：《细胞与分子免疫学杂志》2024年第9期839-843,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(82174330);陕西省科技厅科研基金(2020ZDLSF05-15,2022JQ-965);陕西省科技厅创新团队(2022TD-55);陕西省中医药管理局基金(2021-02-ZZ-004);陕西中医药大学学科创新团队建设项目(2019-YL05)。

摘　　要：自然杀伤(NK)细胞在清除病毒,执行免疫调节方面发挥着重要的作用,它通过分泌趋化因子以及与其他天然免疫细胞协同作用,被赋予天然免疫调节功能和获得性免疫反应。随着对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染的2019冠状病毒病(COVID-19)的研究深入,发现NK细胞在其中发挥着重要作用。SARS-CoV-2感染会影响NK细胞的分布和效应功能,NK细胞的免疫应答或可影响新冠肺炎患者的预后。本文总结了近年来NK细胞在COVID-19感染中作用的研究现状,并且讨论了以NK细胞作为治疗剂的可能性,以期为防治SARS-CoV-2的免疫损害提供潜在思路。Natural killer(NK)cells play an important role in clearing viruses and performing immunomodulation,and they possess innate immunomodulatory functions and acquired immune responses through secreting chemokines and acting in synergy with other natural immune cells.With in-depth studies of coronavirus disease 2019(COVID-19)in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,NK cells have been identified as playing an important role.SARS-CoV-2 infection affects the distribution and effector function of NK cells,and the immune response of NK cells may influence the prognosis of patients with COVID-19.This review summarizes the latest research on the role of NK cells in COVID-19 infection,and discusses their potential as therapeutic agents,aiming to provide insights into the prevention of immune damage caused by SARS-CoV-2.

关 键 词：自然杀伤(NK)细胞 严重急性呼吸综合征冠状病毒2(SARS-CoV-2) 2019冠状病毒病(COVID-19) 免疫治疗 综述 

分 类 号：R563.1[医药卫生—呼吸系统] R392.12[医药卫生—内科学] R457.2[医药卫生—临床医学] G353.11[文化科学—情报学]