先天性胫骨假关节的临床治疗新进展  

Recent advances on clinical treatment of congenital pseudarthrosis of the tibia

作　　者：吴春星[1] 宁波[1] WU Chunxing;NING Bo(Department of Pediatric Orthopedics,Children’s Hospital of Fudan University,Shanghai 201102,China)

机构地区：[1]复旦大学附属儿科医院儿骨科,上海201102

出　　处：《外科研究与新技术（中英文）》2024年第3期181-185,共5页Surgical Research and New Technique

基　　金：国家自然科学基金(82272441);上海市科学技术委员会科技创新行动(22Y11912200)。

摘　　要：先天性胫骨假关节是罕见的先天性胫腓骨骨骼畸形,以骨不连、假关节形成、肢体成角短缩等畸形为主要表现,多合并神经纤维瘤病,治疗极其困难。近年来,随着对先天性胫骨假关节发病机制研究的深入,新型手术方法如胫腓骨“4合1融合术”、“Cross-union内固定法”(胫腓骨交叉融合术)的开展,结合新型药物如双膦酸盐、骨形态发生蛋白的综合使用,其骨愈合率逐渐提高,再骨折发生率降低。本文总结了近年来先天性胫骨假关节治疗的现状及进展,以期为临床治疗提供借鉴和思考。Congenital pseudarthrosis of the tibia(CPT)is a rare tibia disease in childrens orthopedics,which is prone to bone nonunion,pseudarthrosis,and lower limb deformity,and is difficult to cure.Successful treatment remains challenging for orthopedic surgeons,despite many treatments developed for this disease.In recent years,with the in-depth study of CPT,the invention of new surgical methods such as"4-in-1 fusion"and"Cross-union"of tibia and fibula,and the comprehensive use of new drugs such as bisphosphonates and bone morphogenetic proteins,the cure rate has gradually increased and the rate of refracture has reduced.The present status and progress of treatment of CPT in recent years were summarized in this paper,aiming to provide reference for clinical treatment.

关 键 词：先天性胫骨假关节 4合1融合术 Cross-union内固定法 胫腓骨交叉融合术 骨形态发生蛋白 

分 类 号：R726.8[医药卫生—儿科]