外泌体在肾移植中的应用研究进展  

Research progress on application of exosomes in kidney transplantation

作　　者：黄宇诗 郭培鑫 马丽云 惠佳亮 HUANG Yushi;GUO Peixin;MA Liyun;HUI Jialiang(Department of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Organ Transplant,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]南方医科大学南方医院麻醉手术中心,广东广州510515 [2]南方医科大学南方医院器官移植科,广东广州510515

出　　处：《外科研究与新技术（中英文）》2024年第3期243-248,共6页Surgical Research and New Technique

基　　金：广州市科技项目基础与应用基础研究专题(2023A04J2311,2023A04J2306);大学生创新创业训练计划项目(S202312121116)。

摘　　要：肾移植作为终末期肾病的首选治疗手段之一,已在全球范围内被广泛应用,然而肾移植引起的免疫排斥反应和术后并发症等预后不良问题一直存在。如何提高肾移植手术成功率及延长移植肾寿命是当前面临的一大难题。外泌体具有信息传递和物质运输功能,能够参与到肾移植的全过程中,包括辅助术前诊断、干预免疫排斥反应及术后并发症等。本文分别从免疫排斥反应、免疫抑制剂毒性及其他移植后并发症3个方面,阐述外泌体在肾移植术中的重要作用及相关应用进展,以期为临床诊断和治疗提供新思路。As one of the best treatments for end-stage renal disease,kidney transplantation has been widely carried out worldwide.However,due to the problems of immune rejection and postoperative complications in kidney transplantation,how to improve the success rate of kidney transplantation and prolong the life of transplanted kidney is still a major problem.Exosomes participate in the whole process of kidney transplantation,including preoperative diagnosis,postoperative immune rejection and other complications,because of their information transmission and material transport functions.This article expounded the important roles of exosomes in kidney transplantation from three aspects of immune rejection,immunosuppressant toxicity,and other post transplant complications,in order to provide new ideas for clinical diagnosis and treatment.

关 键 词：肾移植 外泌体 免疫排斥反应 

分 类 号：R617[医药卫生—外科学]