前列地尔注射液结合肠内营养支持在冠心病伴营养不良中应用  

Application of alprostadil injection combined with enteral nutrition support in patients with coronary heart disease and malnutrition

作　　者：张帆[1] 黄龙武[1] 李雷[1] Fan Zhang;Long-Wu Huang;Lei Li(Department of Internal Medicine,Huzhou Third People’s Hospital,Huzhou 313000,Zhejiang Province,China)

机构地区：[1]湖州市第三人民医院内科,浙江省湖州市313000

出　　处：《世界华人消化杂志》2024年第9期671-677,共7页World Chinese Journal of Digestology

摘　　要：背景前列地尔注射液具有抑制血小板聚集、扩张冠状动脉、改善血液循环等作用,肠内营养支持可改善机体营养状态,提高机体免疫力,二者联合应用可能对高龄冠心病伴营养不良治疗效果更佳.目的探讨前列地尔注射液结合肠内营养支持对高龄冠心病伴营养不良中应用.方法选取2020-02/2022-02我院142例冠心病伴营养不良患者,随机数字表法分组,各71例.对照组采取常规治疗,研究组基于对照组采取前列地尔注射液结合肠内营养支持,连续治疗1 mo.统计两组左心室射血分数(left ventricular ejection fraction,LVEF)、心绞痛持续时间、心绞痛发作频率、营养状况指标[白蛋白(albumin,ALB)、转铁蛋白(transferrin,Tf)、简易营养评价表(mini-nutritional assessment,MNA)]、微炎症状态指标[微小核糖核酸-196a(miR-196a)、微小核糖核酸-146a(miR-146a)]、不良反应、主要心血管不良事件(major adverse cardiovascular events,MACE)及中国心血管患者生活质量评定问卷(china questionnaire of quality of life in patients with cardiovascular diseases,CQQC)评分.结果治疗1 mo后研究组LVEF高于对照组,心绞痛持续时间、心绞痛发作频率低于对照组(P<0.05);治疗1 mo后研究组ALB、Tf水平及MNA评分高于对照组,miR-196a、miR-146a水平低于对照组(P<0.05);两组治疗1 mo后不良反应及MACE发生率比较,差异无统计学意义;治疗1 mo后两组CQQC评分高于治疗前(P<0.05).结论前列地尔注射液结合肠内营养支持应用于高龄冠心病伴营养不良患者,有助于减轻微炎症状态,改善营养状况,控制心绞痛发作症状.BACKGROUND Alprostadil injection has the effects of inhibiting platelet aggregation,dilating coronary arteries,and improving blood circulation.Enteral nutritional support can improve the nutritional status of the body and enhance its immune function.The combined application of the two may yield better therapeutic effects in elderly patients with coronary heart disease accompanied by malnutrition.AIM To explore the application of alprostadil injection combined with enteral nutrition support in elderly patients with coronary heart disease and malnutrition.METHODS A total of 142 patients with coronary heart disease accompanied by malnutrition treated in our hospital from February 2020 to February 2022 were selected and randomly divided into either a control group or a study group,with 71 cases in each group.Both groups received conventional treatment,and the study group was additionally treated with alprostadil injection combined with enteral nutritional support.Both groups were treated for a continuous period of 1 mo.The left ventricular ejection fraction(LVEF),duration and frequency of angina pectoris,nutritional status indicators[albumin(ALB),transferrin(Tf),and mini-nutritional assessment(MNA)],microinflammatory state indicators[microRNA-196a(miR-196a)and microRNA-146a(miR-146a)],adverse reactions,major adverse cardiovascular events(MACEs),and China questionnaire of quality of life in patients with cardiovascular diseases(CQQC)scores were statistically analyzed for both groups.RESULTS After 1 mo of treatment,the LVEF of the study group was higher than that of the control group,and the duration and frequency of angina pectoris were lower than those of the control group(P<0.05).The levels of ALB,Tf,and MNA in the study group were higher than those in the control group after 1 mo of treatment,while the levels of miR-196a and miR-146a were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions or MACEs between the two groups after 1 mo of treatment(P>0

关 键 词：高龄 冠心病 营养不良 微炎症状态 肠内营养支持 前列地尔注射液 

分 类 号：R541.4[医药卫生—心血管疾病]