溶血磷脂酸调控骨改建作用的研究进展  

Advances in lysophosphatidic acid for bone remodeling

作　　者：张勤 向琳[2] 宫苹[2] ZHANG Qin;XIANG Lin;GONG Ping(Department of Oral Implantology,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Institute of Stomatology,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院种植科,南京市口腔医院,南京大学口腔医学研究所,江苏南京210008 [2]口腔疾病研究全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院种植科,四川成都610041

出　　处：《口腔医学》2024年第9期699-704,共6页Stomatology

基　　金：国家自然科学基金(82170997,82170935)。

摘　　要：溶血磷脂酸(lysophosphatidic acid,LPA)是机体内天然存在的一种小分子甘油磷脂。其在人体内分布广泛,与其受体LPA 1-6结合后,经复杂的下游信号转导机制,介导细胞增殖、迁移等多种细胞学行为,进而参与肿瘤发生发展、炎症、创伤愈合等生物学过程。近年来,LPA在调控骨代谢方面的作用受到越来越多的关注。它一方面可以直接作用于骨相关细胞,另一方面可以作为骨组织中神经-血管-免疫-骨的潜在交联因子,为骨改建提供良好的微环境,进一步影响骨再生。该文就溶血磷脂酸调控骨代谢作用的研究进展作一综述。Lysophosphatidic acid(LPA),a simple bioactive lysophospholipid widely dispersed in human body,has been reported to regulate the proliferation,chemotaxis and differentiation of multiple cells and further participate in various developmental and pathophysiological processes through at least six specific G protein-coupled receptors(GPCRs),LPA1-LPA6.Recently,the possibility of targeting LPA or LPA receptors in bone remodeling has been heatedly discussed.On the one hand,LPA modulate the activities of bone-related cells directly.On the other hand,LPA might be the potential regulator that links the nervous-vascular-immune-skeletal systems,which could provide a good microenvironment for bone remodeling and further promote bone regeneration.Thus,this review summarizes recent studies on the effects and application prospect of LPA on bone remodeling.

关 键 词：溶血磷脂酸 骨改建 G蛋白偶联受体 

分 类 号：R344.3[医药卫生—基础医学]