夫妻双方年龄对夫精人工授精妊娠结局的影响  

The Influence of Marital Age on the Pregnancy Outcome of Artificial Insemination with Husband's Sperm

作　　者：曾倩凌 朱海伦 ZENG Qianling;ZHU Hailun(Center for Reproductive Medicine,Hunan People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha Hunan 410005)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)生殖医学中心,湖南长沙410005

出　　处：《医学临床研究》2024年第9期1285-1288,共4页Journal of Clinical Research

基　　金：湖南省自然科学基金(编号:2022JJ90054)。

摘　　要：【目的】探讨夫妻双方年龄对夫精人工授精(AIH)妊娠结局的影响。【方法】回顾性分析2017年11月至2023年11月在湖南省人民医院生殖医学中心行AIH的110对夫妻,总共行夫精人工授精的周期为202个周期,比较夫妻双方不同年龄组AIH临床妊娠率、自然流产率,女方不同年龄组临床妊娠患者AIH周期数≥3次所占比例,男方不同年龄组精子质量异常率。【结果】女方年龄≥35岁组与年龄<35岁组患者不孕年限、扳机日子宫内膜厚度及扳机日血清雌二醇(E 2)、孕酮(P)水平比较,差异无统计学意义(P>0.05)。女方临床妊娠年龄≥35岁组患者扳机日血清E 2水平低于年龄<35岁组患者,差异有统计学意义(P<0.05);女方年龄≥35岁组临床妊娠周期中自然流产率高于年龄<35岁组,差异有统计学意义(P<0.05)。女方年龄≥35岁组AIH周期数≥3次所占比例显著高于年龄<35岁组,差异有统计学意义(P<0.05)。男方年龄≥35岁组精子质量异常率高于年龄<35岁组,差异有统计学意义(P<0.05)。【结论】女方年龄在一定程度上影响AIH临床妊娠后自然流产发生率,对于年龄≥35岁的不孕患者可考虑更加积极的助孕方式,男方年龄是影响精子质量的重要因素。【Objective】To explore the effect of age on the pregnancy outcome of artificial insemination by husband(AIH).【Methods】A retrospective analysis was conducted on 110 couples who underwent AIH at the Reproductive Medicine Center of Hunan People's Hospital from November 2017 to November 2023.The total number of cycles of artificial insemination with husband's sperm was 202.The clinical pregnancy rate and spontaneous abortion rate of AIH in different age groups of the couples were compared,and the proportion of AIH cycles≥3 in different age groups of the female partner and the abnormal sperm quality rate in different age groups of the male partner were compared.【Results】There was no statistically significant difference(P>0.05)in the duration of infertility,endometrial thickness on trigger day,and serum estradiol(E 2)and progesterone(P)levels between patients aged≥35 and those aged<35.The serum E 2 level on trigger day in patients with clinical pregnancy age≥35 years old was lower than that in patients with age<35 years old,and the difference was statistically significant(P<0.05);The spontaneous abortion rate during the clinical pregnancy cycle in the age group≥35 years old is higher than that in the age group<35 years old,and the difference is statistically significant(P<0.05).The proportion of AIH cycles≥3 times in the female age group≥35 years old was significantly higher than that in the age group<35 years old,and the difference was statistically significant(P<0.05).The abnormal rate of sperm quality in the male age group≥35 years old is higher than that in the age group<35 years old,and the difference is statistically significant(P<0.05).【Conclusion】The age of the female partner has a certain impact on the incidence of spontaneous abortion after AIH clinical pregnancy.For infertile patients aged 35 years or older,more active assisted reproductive methods can be considered.The age of the male partner is an important factor affecting sperm quality.

关 键 词：授精 人工(丈夫供体) 妊娠结局 年龄分布 

分 类 号：R711.6[医药卫生—妇产科学]