阿贝西利致乳腺癌骨转移患者假性血肌酐升高  

Pseudo-elevation of serum creatinine due to abemaciclib in a patient with bone metastasis of breast cancer

作　　者：陈敏婷 刘岩[2] 马杰[2] 郑可[2] Chen Minting;Liu Yan;Ma Jie;Zheng Ke(Department of Internal Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Nephrology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院肾内科,北京100730

出　　处：《药物不良反应杂志》2024年第9期563-565,共3页Adverse Drug Reactions Journal

基　　金：中央高水平医院临床研究业务费项目(2022-PUMCH-A-172);北京协和医学院教学改革项目(2021zlgc0125)。

摘　　要：1例53岁女性乳腺癌骨转移患者同时接受靶向药物(阿贝西利150 mg口服、2次/d,依西美坦25 mg口服、1次/d)、唑来膦酸(4 mg静脉滴注、1次/月)、中药和非甾体抗炎药治疗。2个月后患者血清肌酐(Scr)由治疗前的84μmol/L升至156μmol/L。因行肾组织穿刺活检,患者漏服阿贝西利1 d,次日复查Scr由入院时的151μmol/L降至123μmol/L。对比使用血清胱抑素C计算的估算肾小球滤过率(eGFR)和使用Scr计算的eGFR,结合肾组织穿刺病理检查结果,可排除其他药物导致的肾损伤,考虑阿贝西利导致的假性Scr升高可能性大。A 53-year-old female patient with bone metastasis of breast cancer received targeted drugs(abemaciclib 150 mg orally twice daily,exemestane 25 mg orally once daily),zoledronic acid(4 mg IV infusion once per month),traditional Chinese medicine,and non-steroidal anti-inflammatory drugs.After 2 months,her serum creatinine(Scr)increased from 84μmol/L before treatment to 156μmol/L.Due to renal tissue puncture biopsy,the patient missed taking abemaciclib for 1 day.The laboratory tests next day showed that her Scr decreased from 151μmol/L to 123μmol/L.Comparing the estimated glomerular filtration rate calculated using serum cystatin C with that calculated using Scr,combined with the pathological examination results of renal biopsy tissue,the patient′s renal injury caused by other drugs could be ruled out,and the possibility of pseudo-elevation of Scr caused by abemaciclib was considered.

关 键 词：乳腺肿瘤 肿瘤转移 假性血肌酐升高 阿贝西利 

分 类 号：R969[医药卫生—药理学]