康妇炎胶囊致肝损伤  

Liver injury induced by Kangfuyan capsules(康妇炎胶囊)

作　　者：王慧敏[1] Wang Huimin(Department of Pharmacy,Heping Hospital Affiliated to Changzhi Medical College,Shanxi Province,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院药剂科,长治046000

出　　处：《药物不良反应杂志》2024年第9期566-568,共3页Adverse Drug Reactions Journal

摘　　要：1例40岁女性患者因宫颈糜烂自行服用康妇炎胶囊每次1.2 g(3粒)、3次/d。服药10 d后患者出现纳差、恶心;间断服药约30 d后症状未好转,实验室检查示丙氨酸转氨酶(ALT)793 U/L,天冬氨酸转氨酶(AST)699 U/L,总胆红素(TBil)27.4μmol/L,碱性磷酸酶(ALP)130 U/L。诊断为药物性肝损伤,考虑与康妇炎胶囊有关。停用该药,予保肝治疗。治疗16 d后患者上述症状改善,实验室检查示ALT 79 U/L,AST 55 U/L,ALP 79 U/L;30 d后,实验室检查示ALT 44 U/L,AST 40 U/L,ALP 51 U/L,TBil 21.5μmol/L。A 40-year-old female patient took Kangfuyan capsules 1.2 g(3 capsules)thrice daily orally by herself for cervical erosion.After 10 days of treatment,the patient developed anorexia and nausea;after taking the drug intermittently for about 30 days,the symptoms were not improved.Laboratory tests showed alanine aminotransferase(ALT)793 U/L,aspartate aminotransferase(AST)699 U/L,total bilirubin(TBil)27.4μmol/L,and alkaline phosphatase(ALP)130 U/L.Drug-induced liver injury was diagnosed,which was considered to be related to Kangfuyan capsules.The drug was stopped,and the liver-protective treatments were given.Sixteen days later,the above symptoms in the patient were improved,laboratory tests showed ALT 79 U/L,AST 55 U/L,and ALP 79 U/L;30 days later,laboratory tests showed ALT 44 U/L,AST 40 U/L,ALP 51 U/L,and TBil 21.5μmol/L.

关 键 词：植物药疗法 化学和药物性肝损伤 药物相关副作用和不良反应 康妇炎胶囊 

分 类 号：R969.3[医药卫生—药理学]