川崎病患儿血清Cav-1、sLR11水平与冠状动脉病变严重程度的相关性分析  

Correlation between levels of serum caveolin-1 and soluble low density lipoprotein receptor 11 and severity of coronary artery lesions in child patients with Kawasaki disease

作　　者：高建波[1] 李娜[1] 郑伟伟[1] 许丽萍 Gao Jianbo;Li Na;Zheng Weiwei;Xu Liping(Department of Pediatrics,People’s Hospital of Jiyuan City,Henan Province,Jiyuan 459000,China;不详)

机构地区：[1]河南省济源市人民医院儿科,济源459000 [2]河南省儿童医院/郑州儿童医院,郑州451161

出　　处：《中国循证心血管医学杂志》2024年第8期952-955,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：河南省医学科技攻关计划科学项目(LHGJ20210647)。

摘　　要：目的 分析川崎病(KD)患儿血清小窝蛋白-1(Cav-1)、可溶性低密度脂蛋白受体11(sLR11)与冠状动脉病变(CAL)严重程度的关系。方法 回顾性分析2021年2月至2022年10月于济源市人民医院儿科收治的153例KD合并CAL患儿的临床资料。依据KD患儿CAL病变程度分为单支病变组(n=54)、双支病变组(n=68)和多支病变组(n=31)。对比三组患儿临床资料、血清Cav-1、sLR11水平。Logistic多因素回归分析影响KD患儿CAL严重程度的相关因素。受试者工作特征曲线(ROC)分析血清Cav-1、sLR11对KD患儿CAL严重程度的预测价值。结果 单支病变组、双支病变组和多支病变组患儿发热持续时间、C反应蛋白(CRP)、血小板(PLT)计数、红细胞沉降率(ESR)、血清Cav-1、sLR11水平依次升高(P<0.05)。多因素分析结果显示治疗前发热持续时间(OR=1.772,95%CI:1.054~2.982,P=0.031)、血清Cav-1(OR=1.139,95%CI:1.080~1.201,P<0.01)及sLR11(OR=1.251,95%CI:1.105~1.417,P<0.01)均为影响KD患儿CAL严重程度的危险因素。ROC分析显示,血清Cav-1、sLR11两者联合预测KD患儿CAL严重程度的AUC为0.910(95%CI:0.854~0.951,P<0.01)。结论 血清Cav-1、sLR11两者联合对KD患儿CAL严重程度的预测效能较高。Objective To analyze the relationship among serum caveolin-1(Cav-1),soluble low density lipoprotein receptor 11(sLR11)and severity of coronary artery lesions(CAL)in child patients with Kawasaki disease(KD).Methods The clinical materials of child patients with KD complicated by CAL(n=153)were retrospectively analyzed in Department of Pediatrics in People’s Hospital of Jiyuan City from Feb.2021 to Oct.2022.All patients were divided,according to CAL severity,into 1-vessel lesion group(n=54),2-vessel lesion group(n=68)and multi-vessel lesion group(n=31).The clinical materials and levels of serum Cav-1 and sLR11 were compared among 3 groups.The relative factors affecting CAL severity were analyzed by using multi-factor Logistic regression analysis in KD patients.The predictive value of Cav-1 and sLR11 to CAL severity were analyzed by using ROC curve in KD patients.Results The duration of fever,C-reactive protein(CRP),platelet(PLT)count,erythrocyte sedimentation rate(ESR),and levels of serum Cav-1 and sLR11 increased in turn in 1-vessel lesion group,2-vessel lesion group and multi-vessel lesion group(P<0.05).The results of multi-factor Logistic regression analysis showed that duration of fever before treatment(OR=1.772,95%CI:1.054~2.982,P=0.031),Cav-1(OR=1.139,95%CI:1.080~1.201,P<0.01)and sLR11(OR=1.251,95%CI:1.105~1.417,P<0.01)were risk factors affecting CAL severity in KD patients.The results of ROC curve analysis showed that AUC of combination of Cav-1 and sLR11 was 0.910(95%CI:0.854~0.951,P<0.01)in predicting CAL severity KD patients.Conclusion The combination of Cav-1 and sLR11 has a higher predictive efficacy for CAL severity in KD patients.

关 键 词：川崎病 冠状动脉病变 小窝蛋白-1 可溶性低密度脂蛋白受体11 

分 类 号：R725.4[医药卫生—儿科]