血清NGF、TPH、GDNF、外周血NLR、PLR水平与双相情感障碍患者认知功能的关系  

Relationship between serum NGF,TPH,GDNF,peripheral blood NLR and PLR levels and cognitive function in patients with bipolar disorder

作　　者：杨静巧 杨九州 王剑萍 YANG Jingqiao;YANG Jiuzhou;WANG Jianping(Department of Emotional Disorders,Henan Rongkang Hospital,Luoyang,Henan,China,471000)

机构地区：[1]河南省荣康医院情感障碍科,河南洛阳471000

出　　处：《分子诊断与治疗杂志》2024年第9期1771-1774,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技发展计划项目(232102311131)。

摘　　要：目的研究血清神经生长因子(NGF)、色氨酸羟化酶(TPH)、神经胶质细胞源性的神经营养因子(GDNF)及外周血中性粒细胞-淋巴细胞比(NLR)、血小板-淋巴细胞比(PLR)水平与双相情感障碍患者认知功能的关系。方法以2021年3月至2023年3月河南省荣康医院收治的65例双相情感障碍患者作为A组,选取同期在该院进行体检的73名健康体检者作为B组,统计两组一般资料,比较两组血清NGF、TPH、GDNF、外周血NLR、PLR水平及认知功能,采用Pearson分析双相情感障碍患者血液学指标与认知功能的相关性。结果A组血清NGF、TPH、GDNF水平及蒙特利尔认知评估量表各项评分低于B组,外周血NLR、PLR水平高于B组,差异有统计学意义(P<0.05)。Pearson分析结果显示,双相情感障碍患者血清NGF、TPH、GDNF水平与蒙特利尔认知评估量表各项评分呈显著正相关(P<0.05),外周血NLR、PLR水平与蒙特利尔认知评估量表各项评分呈显著负相关关系(P<0.05)。结论与健康体检者相比,双相情感障碍患者血清NGF、TPH、GDNF、外周血NLR、PLR水平及认知功能存在明显变化,两者之间具有明显相关性。Objective To study the relationship between the levels of serum nerve growth factor(NGF),tryptophan hydroxylase(TPH),glial cell-derived neurotrophic factor(GDNF),neutrophil-lympho-cyte ratio(NLR)and platelet-lymphocyte ratio(PLR)and cognitive function in patients with bipolar disorder.Methods 65 patients with bipolar disorder admitted to Henan Rongkang Hospital from March 2021 to March 2023 were selected as group A,and 73 healthy individuals who underwent physical examinations at the hospital during the same period were selected as group B.General data from both groups were analyzed including serum levels of NGF,TPH,and GDNF,peripheral blood NLR,PLR and cognitive function.A comparison was made between the two groups.Pearson correlation analysis was used to examine the relationship between hema-tological indexes and cognitive function in patients with bipolar disorder.Results The levels of serum NGF,TPH,and GDNF,as well as the scores of the montreal cognitive assessment scale in group A were lower than those in group B,and the levels of peripheral blood NLR and PLR were higher than those in group B(P<0.05).Pearson's analysis showed that serum levels of NGF,TPH,and GDNF in bipolar disorder patients were significantly positively correlated with scores of montreal cognitive assessment scale(P<0.05).Further-more,peripheral blood NLR and PLR showed a significant negative correlation with scores on montreal cogni-tive assessment scale(P<0.05).Conclusion Compared to healthy subjects,the levels of serum NGF,TPH,and GDNF,peripheral blood NLR,PLR and cognitive function in patients with bipolar disorder had signifi-cant changes,and there was a significant correlation between the two factors.

关 键 词：双相情感障碍 神经生长因子 色氨酸羟化酶 神经胶质细胞源性的神经营养因子 中性粒细胞-淋巴细胞比 血小板-淋巴细胞比 

分 类 号：R446.11[医药卫生—诊断学] R749.4[医药卫生—临床医学]