早发性卵巢功能不全与自身免疫性甲状腺病的相关性研究进展  

Research progress on the correlation between premature ovarian insufficiency and autoimmune thyroid disease

作　　者：薛智云 李斌 陈秀英 XUE Zhi-yun;LI Bin;CHEN Xiu-ying(Department of Gynecology,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院妇科,上海200011

出　　处：《复旦学报（医学版）》2024年第5期820-824,共5页Fudan University Journal of Medical Sciences

基　　金：上海市自然科学基金(22ZR1408700)。

摘　　要：早发性卵巢功能不全(premature ovarian insufficiency,POI)的发病率不断增加且有年轻化趋势,POI不仅影响女性的生育能力,而且存在雌激素低下的近远期风险。POI的病因复杂且呈高度异质性,包括遗传因素、医源性因素、自身免疫功能障碍、感染和环境因素等,但以特发性POI居多。近年来,许多研究聚焦自身免疫性疾病与POI的相关性,其中研究较多的是自身免疫性甲状腺病(autoimmune thyroid disease,AITD)。本文将从POI的免疫相关现状,AITD的致病机制以及相关治疗进展进行综述。The incidence of premature ovarian insufficiency(POI)is increasing and showing a trend of affecting younger women,which not only affects women’s fertility,but also has the risk of low estrogen in the short and long term.The etiology of POI is complex and highly heterogeneous,including genetic factors,iatrogenic factors,autoimmune dysfunction,infection and environmental factors,but idiopathic POI still accounts for the majority.A lot of researches have focused on the correlation between autoimmune diseases and POI,among which autoimmune thyroid disease(AITD)plays an important role.Therefore,this article will review the current status of POI,the possible pathogenesis of AITD and related treatment progress.

关 键 词：早发性卵巢功能不全(POI) 自身免疫性甲状腺病(AITD) 发病机制 

分 类 号：R581.2[医药卫生—内分泌] R711.75[医药卫生—内科学]