肿瘤相关成纤维细胞分子影像学研究进展  

ADVANCES IN MOLECULAR IMAGING OF TUMOR-ASSOCIATED FIBROBLASTS

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作  者:白家瑞 赵开通 张国建[2] BAI Jiarui;ZHAO Kaitong;ZHANG Guojian(College of first Clinical Medical,Inner Mongolia Medical University,Hohhot 010059,China;Department of Nuclear Medicine,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区:[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050

出  处:《内蒙古医科大学学报》2024年第3期305-310,共6页Journal of Inner Mongolia Medical University

基  金:国家自然科学基金项目(81960319);内蒙古自治区自然科学基金项目(2021MS08085);内蒙古医科大学面上项目(YKD2021MS012);内蒙古医科大学致远人才项目(ZY0202037)。

摘  要:肿瘤相关成纤维细胞(cancer-associatedfibroblasts,CAFs)分类于肿瘤基质细胞大类,参与构成了肿瘤微环境(tumormicroenvironment,TME)。目前有明确研究表明,CAFs在TME系统中参与了激活某些信号通路以及分泌一些细胞因子,促进了肿瘤的增殖、耐药性以及免疫抑制。随着CAFs各亚型标志物如成纤维细胞活化蛋白(cancer-associatedfibroblasts,FAP)、α-平滑肌动蛋白(α-smoothactin,α-SMA)的表达特点逐步得到揭示,促使我们开始应用分子影像学技术从活体分子水平上可视化、描述和测量CAFs,应用分子影像学技术靶标CAFs进行肿瘤诊断性显像与治疗的构想也开始得到实践。本文将对基于肿瘤微环境理论,以及与肿瘤相关成纤维细胞相关的分子影像学研究进展加以综述。Tumor-associated fibroblasts(cancer-associatedfibroblasts,CAFs)are classified into tumor stromal cells and participate in the formation of tumor microenvironment(tumormicroenvironment,TME).At present,clear studies have shown that CAFs is involved in activating some signal pathways and secreting some cytokines in the TME system,which promotes tumor proliferation,drug resistance and immunosuppression.With the gradual revelation of the expression characteristics of various subtype markers of CAFs,such as fibroblast activating protein(FAP)andα-smooth actin(α-SMA),we begin to use molecular imaging techniques to visualize,describe and measure CAFs at the molecular level,and the idea of using molecular imaging technology target CAFs for tumor diagnostic imaging and treatment has also been realized.In this paper,the research progress of molecular imaging based on tumor microenvironment theory and tumor-related fibroblasts is reviewed.

关 键 词:肿瘤微环境 肿瘤相关成纤维细胞 成纤维激活蛋白 成纤维激活蛋白抑制剂 

分 类 号:R464.3[医药卫生—临床医学]

 

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