脑源性神经营养因子介导帕金森病的运动防治:作用与机制  

Exercise prevention and treatment of Parkinson’s disease mediated by brain-derived neurotrophic factor:role and mechanism

作　　者：雷森林 谌晓安[1] 陈平 王兆锋 Lei Senlin;Chen Xiaoan;Chen Ping;Wang Zhaofeng(College of Physical Education,Jishou University,Jishou 416000,Hunan Province,China;School of Physical Education,Beibu Gulf University,Qinzhou 535000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]吉首大学体育科学学院,湖南省吉首市416000 [2]北部湾大学体育学院,广西壮族自治区钦州市535000

出　　处：《中国组织工程研究》2025年第25期5454-5468,共15页Chinese Journal of Tissue Engineering Research

基　　金：湖南省自然科学基金(2021JJ30552),项目负责人:陈平;国家民族体育重点研究基地开放基金项目(MZTY2203),项目负责人:陈平;湖南省教育厅科学研究重点项目(20A414),项目负责人:陈平。

摘　　要：背景:运动干预作为经济有效的非物理疗法,可有效上调脑源性神经营养因子表达进而防治帕金森病发生发展,但目前关于靶向脑源性神经营养因子的运动治疗策略在延缓帕金森病发生发展的潜在作用机制尚不明晰。目的:以脑源性神经营养因子和帕金森病的关系为切入点,分析帕金森病病理状态下运动对脑源性神经营养因子表达的特异性调控作用及机制,梳理脑源性神经营养因子介导下不同运动方式对帕金森病的改善效果,并阐明靶向脑源性神经营养因子的运动治疗策略在防治帕金森病的潜在作用机制,旨在为运动防治帕金森病提供新的理论依据。方法:以“帕金森病,脑源性神经营养因子,神经保护,多巴胺,神经元异常凋亡,神经炎症反应,突触可塑性,运动”等为中文检索词;以“Parkinson’s disease,BDNF,Neuroprotection,neuroinflammation,synaptic plasticity”等为英文检索词,分别检索中国知网、万方数据库、PubMed和Web of Science数据库,搜寻各数据库建库至2024年2月发表的所有研究文献,根据纳排标准共获得核心相关文献98篇。结果与结论:①在帕金森病理背景下,运动可通过促进肌因子鸢尾素大量分泌,并降低色氨酸-犬尿氨酸代谢途径紊乱特异性调控脑源性神经营养因子表达。②有氧运动,尤其是特殊有氧运动(动物:旋转杆步行/人类:北欧健走)以及多模式运动可显著上调脑源性神经营养因子表达,进而改善帕金森病的运动症状,此外脑源性神经营养因子还介导身心运动(太极拳)对帕金森病患者认知障碍和睡眠障碍等非运动症状的有效调节。③运动诱导的高表达脑源性神经营养因子可能通过上调抗炎因子白细胞介素10、神经生长因子β和转化生长因子β表达,下调促炎因子肿瘤坏死因子α及白细胞介素1β表达,并抑制核转录因子κB信号通路表达降低小胶质细胞活性减轻神经炎症�BACKGROUND:Exercise interventions,recognized for their economic and non-pharmaceutical efficacy,have demonstrated the potential to upregulate brain-derived neurotrophic factor levels,thereby offering a therapeutic approach to the prevention and management of Parkinson’s disease.However,the specific mechanisms by which exercise targeting brain-derived neurotrophic factor expression to delay Parkinson’s disease onset and progression are not clear.OBJECTIVE:To explore the interplay between brain-derived neurotrophic factor and Parkinson’s disease,to analyze the specific regulatory effect and mechanism of exercise on the expression of brain-derived neurotrophic factor in the pathological state of Parkinson’s disease,to review the improvement effect of different exercise methods mediated by brain-derived neurotrophic factor on Parkinson’s disease,to clarify the potential mechanism of exercise therapy targeting brain-derived neurotrophic factor in the prevention and treatment of Parkinson’s disease,in order to provide a new theoretical basis for exercise prevention and treatment of Parkinson’s disease.METHODS:A systematic literature review was conducted using“Parkinson’s disease,brain-derived neurotrophic factor,neuroprotection,dopamine,neuronal apoptosis,neuroinflammation,and synaptic plasticity”as Chinese keywords,and“Parkinson’s disease,BDNF,neuroprotection,neuroinflammation,and synaptic plasticity”as English keywords.Databases including CNKI,WanFang Data,PubMed,and Web of Science were searched for relevant articles published up to February 2024.Totally 98 core articles were selected based on inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1)Within the pathophysiological framework of Parkinson’s disease,exercise has been shown to stimulate the release of the myokine Irisin and to specifically enhance brain-derived neurotrophic factor expression,counteracting kynurenine pathway metabolic dysregulation.(2)Aerobic activities,notably specialized forms such as Running on a Wheel with

关 键 词：运动 帕金森病 脑源性神经营养因子 神经保护 神经炎症 多巴胺 Α-突触核蛋白 突触可塑性 神经元凋亡 非运动症状 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学] R754.2