群体感应介导细菌-噬菌体间相互作用的研究进展  

Research progress on quorum sensing mediating bacterial-bacteriophage interactions

作　　者：高苗 凌保东[1,2] GAO Miao;LING Baodong(College of Pharmacy,Chengdu Medical College,Chengdu 610500,China;Sichuan Province CollegeKey Laboratory of Structure-Specific Small Molecule Drugs,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院药学院,成都610500 [2]成都医学院结构特异性小分子药物研究四川省高校重点实验室,成都610500

出　　处：《生物学杂志》2024年第5期94-99,共6页Journal of Biology

基　　金：国家自然科学基金面上项目(81373454)。

摘　　要：群体感应系统作为微生物间至关重要的通信机制,与细菌-噬菌体存在着密切的相互作用关系。综述群体感应系统在介导细菌生物被膜形成、细菌各种表面蛋白的形成、原核生物适应性免疫系统来抵抗噬菌体感染的作用和调控噬菌体裂解-溶源决策以优化噬菌体自身生存与繁殖的作用。通过对群体感应系统在细菌-噬菌体间相互作用研究结果的整理和总结,期望能够为全面深入探索群体感应系统在细菌-噬菌体间作用机制提供参考,为噬菌体控制耐药病原菌的传播和治疗提供理论依据。The quorum sensing system,as a critically important communication mechanism among microorganisms,has a close and intricate interaction with the bacteria-bacteriophage.This paper reviewed the role of quorum sensing systems in mediating the formation of bacterial biofilms,the synthesis of various surface proteins in bacteria,the role of prokaryotic adaptive immune systems in resisting bacteriophage infections,and regulation of the switch of phage lysis-lysogeny to optimize phage survival and reproduction.By summarizing the research results on the interactions between the quorum sensing system and bacteria-bacteriophage,it was hoped this effort would provide a comprehensive exploration of the mechanisms underlying the quorum sensing system interaction between bacteria-bacteriophages,which provided the theoretical basis for phage control of the spread and treatment of drug-resistant pathogens.

关 键 词：噬菌体 群体感应 生物被膜 CRISPR-Cas系统 裂解-溶源决策 

分 类 号：Q939.48[生物学—微生物学]