清气化痰汤加减治疗痰热壅肺型重症肺炎的临床研究  

Modified Qingqi Huatan Decoction Treats Severe Pneumonia in Patients with Syndrome of Phlegm-Heat Obstructing Lung

作　　者：李松滨 许献文 方统武 LI Songbin;XU Xianwen;FANG Tongwu(The Fifth People’s Hospital of Nanhai District,Foshan 528000,China)

机构地区：[1]佛山市南海区第五人民医院,广东佛山528000

出　　处：《基层中医药》2024年第9期12-17,共6页Basic Traditional Chinese Medicine

基　　金：佛山市卫生健康局2021年立项课题(20210439)。

摘　　要：目的 探讨清气化痰汤加减对痰热壅肺型重症肺炎的治疗效果。方法 选取我院ICU科于2021年2月—2023年6月期间收治的符合条件的痰热壅肺型重症肺炎患者80例,将其随机分为两组,每组各40例。对照组采用西医抗感染、机械通气、解痉平喘、痰液引流、肠内营养支持等综合治疗。观察组在此基础上联合中药颗粒方剂“清气化痰汤加减”治疗,每天1剂,分2次口服或鼻饲。两组疗程均为10 d。记录两组患者治疗前、治疗后的血清炎症指标CRP、PCT。观察两组患者治疗前、治疗后体温、呼吸频率、休克、氧合指数、分泌物、胸部影像、机械通气情况,按等级积分法算出临床症状体征评分,以积分变化来评定疗效。结果 经过治疗后,两组患者的血清炎症指标(CRP、PCT)均明显下降,上述指标观察组下降更明显(P <0.05)。观察组疗效评价高于对照组(P <0.05)。结论 清气化痰汤加减参与治疗痰热壅肺型重症肺炎有良好疗效,可在临床加以推广。Objective To explore the clinical effect of Qingqi Huatan Decoction on severe pneumonia in the patients with the syndrome of phlegm-heat obstructing lung.Methods Eighty patients with severe pneumonia due to phlegm-heat obstructing lung treated in the department of intensive care unit of the Fifth People’s Hospital of Nanhai District from February 2021 to June 2023 were selected and randomized into two groups(n=40).The control group only accepted comprehensive treatment of Western medicine,including anti-infection intervention,mechanical ventilation,convulsion and asthma relieving,phlegm drainage,and enteral nutrition support.The observation group received modified Qingqi Huatan Decoction orally or nasally twice per day onthe basis of the therapy in the control group. Both groups were treated for 10 days. The serum levelsof C-reactive protein (CRP) and procalcitonin (PCT) were measured before and after treatment. Inaddition, the body temperature, respiratory rate, shock, oxygenation index, secretions, chest image,and mechanical ventilation of the two groups were observed before and after treatment. The clinicalsymptoms and signs were graded and scored, and the clinical efficacy was evaluated based on thescores. Results After treatment, the serum levels of CRP and PCT declined in both groups and theywere lower in the observation group than in the control group (P <0.05). The clinical efficacy in theobservation group was higher than that in the control group (P <0.05). Conclusion Modified QingqiHuatan Decoction is effective in the treatment of severe pneumonia in the patients with the syndromeof phlegm-heat obstructing lung and should be promoted in clinical practice.

关 键 词：清气化痰汤 重症肺炎 痰热壅肺证 中医药治疗 

分 类 号：R47[医药卫生—护理学]