某精神专科医院第二类精神药品药物依赖的主动监测模式探讨  

Discussion about active monitoring mode of the Class Ⅱ PsychotropicDrug Dependence in A Psychiatric Hospital

作　　者：蒋雷 王涛 黄元[3] Jiang Lei;Wang Tao;Huang Yuan(Department of Pharmacy and Machinery,Tai’an Psychiatric Hospital,Shandong Tai'an 271000;Tai'an Food and Drug Inspection and Research Institute,Shandong Tai'an 271000;Shandong Center for Adverse Drug Reaction Monitoring,Shandong 250014)

机构地区：[1]泰安市精神病医院药剂科,山东泰安271000 [2]泰安市食品药品检验检测研究院,山东泰安271000 [3]山东省药品不良反应监测中心,山东济南250014

出　　处：《中国药物滥用防治杂志》2024年第9期1591-1594,1604,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：山东省药品监督管理局药品不良反应监测中心项目(编号:2022SDADRKY11)。

摘　　要：目的:探讨精神专科医院中第二类精神药品药物依赖的主动监测模式,以提升监测效率。方法:提取2020—2022年门诊精二药品处方信息,根据“超剂量”和“精二药品联合使用”两项指标筛查处方中的风险信号,建立药物依赖可疑人群数据库,并使用标准化访谈问卷进行药物依赖评定。根据评定结果将可疑人群分为依赖组和非依赖组,分析产生药物依赖的风险因素。结果:筛查共发现筛查共发现5728张可疑处方,涉及568名疑似药物依赖患者,其中68人评定为药物依赖。两组间单因素分析和Logistic多因素分析结果显示,精二药品联用、高龄和长期用药是导致药物依赖发生的独立风险因素,且具有统计学意义(P<0.05)。结论:本研究建立的使用“超剂量”和“精二药品联合使用”作为筛查工具的药物依赖主动监测方法可行,值得进一步研究推广。Objective:To discuss about active monitoring mode of classⅡpsychotropic drug dependence in the outpatient department in a psychiatric hospital,in order to improve monitoring efficiency.Methods:Extracted the prescription information of outpatient’s second class psychotropic drugs from 2020 to 2022.Screening for risk signals in prescriptions based on two indicators“:overdose”and“combined use of psychotropic drugs”.Then established a database of suspected drug dependence populations,and Used standardized interview questionnaires for drug dependence assessment.According to the assessment results,the suspicious population was divided into dependent and non dependent groups,and the risk factors for drug dependence are analyzed.Results:A total of 5728 suspicious prescriptions were found during screening,referring 568 suspected drug dependent patients,68 of them were rated as drug dependent.The results of uni-variate analysis and multivariate logistic regression between the two groups showed that The combination of psychotropic substances,advanced age,and long-term use of drugs are independent risk factors leading to drug dependence,and the difference is statistically significant(P<0.05).Conclusion:The active monitoring method for drug dependence established in this study using“overdose”and“combined use of psychotropic drugs”as screening tools is feasible.This model is worth further research and promotion.

关 键 词：第二类精神药品 标准化访谈问卷 药物依赖 主动监测 

分 类 号：R95[医药卫生—药学]